Patent US4483849A successfully refreshed from Google Patents.
US4483849A
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US
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Stabilization and purification of interferon with propylene glycol, resulting in a non-toxic product
Assignee: HEM-SUB Inc A CORP OF
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Filing: 1983-01-07
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Granted: 1984-11-20
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Expires: 2003-01-07
Abstract
Abstract A new process for stabilizing purified human interferon is described, using propylene glycol. Propylene glycol also aids in the interferon purification procedure. Older methods used stabilizing agents which are toxic, antigenic or irritating. The new process will make available significantly more interferon of clinical purity for use in patients with cancer, viral illnesses and other diseases as yet undesignated (e.g. multiple sclerosis, amyotropic lateral sclerosis, scleroderma, etc.).
Inventors
- 👤 William A. Carter
- 👤 Gerald Silver
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:10
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/555; C07K14/565
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
42 words
A process for purifying and stabilizing interferon, comprising the steps of: adding an interferon-containing fluid to a solid purification matrix; eluting said interferon from said matrix with a solution containing propylene glycol; and storing said interferon in a solution containing propylene glycol.
Claim 2
Dependent Claim
42 words
A process for purifying and stabilizing interferon, comprising the steps of: adding an interferon-containing fluid to a solid purification matrix; eluting said interferon from said matrix with a solution containing propylene glycol; and storing said interferon in a solution containing propylene glycol.
Claim 3
Dependent Claim
14 words
A process according to claim 1 wherein said solid matrix is a hydrophobic ligand.
Claim 4
Dependent Claim
12 words
A process according to claim 1 wherein said solid matrix is Remazol.
Claim 5
Dependent Claim
14 words
A process according to claim 1 wherein said solid matrix is Cibacron blue F3G-A.
Claim 6
Dependent Claim
13 words
A process according to claim 1 wherein said solid matrix is Affi-gel Blue.
Claim 7
Dependent Claim
29 words
A process according to claim 1 wherein said propylene glycol containing solution is a 1:1 mixture of propylene glycol and 1M NaCl buffered at neutral pH with sodium phosphate.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-20 | 1988-05-21 | 1988-11-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-20 | 1992-05-21 | 1992-11-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-20 | 1996-05-21 | 1996-11-20 | $7700.00 | Window Closed / Lapsed |