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US4482559A Expired / Lapsed US ⏱️ 0.0 years remaining

4-Phenyl-4,5,6,7-tetrahydro-thieno [2,3-c]pyridines, compositions and use

Assignee: Boehringer Ingelheim GmbH
•
Filing: 1983-02-14
•
Granted: 1984-11-13
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Expires: 2003-02-14
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Abstract

Abstract Compounds of the formula <IMAGE> (I) wherein R1 is amino, acetylamino, hydroxymethyl, methoxymethyl or <IMAGE> R2 and R3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl; R4 is straight or branched alkyl of 1 to 3 carbon atoms; and R5 and R6, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocyclic ring where, in the case of a 6-membered ring, a -CH2-group in the ring may be replaced by an oxygen atom, and non-toxic, pharmacologically acceptable salts thereof. The compounds as well as their salts are useful as antidepressants.

Inventors

  • 👤 Claus Schneider
  • 👤 Gerhard Walther
  • 👤 Karl-Heinz Weber
  • 👤 Wolf D. Bechtel
  • 👤 Karin Boke-Kuhn

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 16:25
CPC Classifications
C; C07; C07D; C07D495/00; C07D495/02; C07D495/04; A; A61; A61P; A61P25/00; A61P25/24; A61P25/26; H; H04; H04B; H04B17/00; H04B17/40

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 48 words
A compound of the formula ##STR13## wherein R 1 is hydroxymethyl, R 2 and R 3 are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl; R 4 is straight or branched alkyl of 1 to 3 carbon atoms, or a non-toxic, pharmacologically acceptable salt thereof.
Claim 2
Dependent Claim 48 words
A compound of the formula ##STR13## wherein R 1 is hydroxymethyl, R 2 and R 3 are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, methoxy, methyl or ethyl; R 4 is straight or branched alkyl of 1 to 3 carbon atoms, or a non-toxic, pharmacologically acceptable salt thereof.
Claim 3
Dependent Claim 15 words
A compound of claim 2, which is 2-(hydroxy-methyl)-4-p-tolyl-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine or a non-toxic, pharmacologically acceptable salt thereof.
Claim 4
Dependent Claim 22 words
An antidepressant pharmaceutical composition consisting essentially of an inert pharmaceutical carrier and an effective antidepressant amount of a compound of claim 1.
Claim 5
Dependent Claim 34 words
The method of preventing or relieving depression in a warm-blooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective antidepressant amount of a compound of claim 1.

References Cited (Backward Citations)

US3823151A Cited
US3705910A Cited
US4104390A Cited
US4322423A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1987-11-13 1988-05-14 1988-11-13 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1991-11-13 1992-05-14 1992-11-13 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1995-11-13 1996-05-14 1996-11-13 $7700.00 Window Closed / Lapsed

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