Patent US4477429A successfully refreshed from Google Patents.
US4477429A
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US
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Oral compositions comprising N.sup.α -alkyl derivatives of arginine
Assignee: Johnson and Johnson Consumer Inc
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Filing: 1982-08-26
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Granted: 1984-10-16
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Expires: 2002-08-26
Abstract
Abstract Oral hygiene formulations incorporating N.sup.α -alkyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.
Inventors
- 👤 Steven B. Silbering
- 👤 Tibor Sipos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:45
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61Q; A61Q11/00
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
25 words
N.sup.α -alkyl derivatives of arginine having the formula: ##STR5## where y is an integer of from 6 to 29, and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
25 words
N.sup.α -alkyl derivatives of arginine having the formula: ##STR5## where y is an integer of from 6 to 29, and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
39 words
A compound of claim 1 wherein said pharmaceutically acceptable salts are selected from the group consisting of alkali metal salts, alkaline earth metal salts, amphoteric metal salts, heavy metal salts, organic base salts, and organic and inorganic acid salts.
Claim 4
Dependent Claim
15 words
The compound of claim 1 wherein said N.sup.α -alkyl derivative of arginine is N.sup.α -octylarginine.
Claim 5
Dependent Claim
15 words
The compound of claim 1 wherein said N.sup.α -alkyl derivative of arginine is N.sup.α -decylarginine.
Claim 6
Dependent Claim
53 words
A composition of matter for oral hygiene to inhibit acid production by microorganisms in the oral cavity comprising an effective amount, in a pharmaceutically acceptable carrier, of an N.sup.α -alkyl derivative of arginine having the formula: ##STR6## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
53 words
A composition of matter for oral hygiene to inhibit acid production by microorganisms in the oral cavity comprising an effective amount, in a pharmaceutically acceptable carrier, of an N.sup.α -alkyl derivative of arginine having the formula: ##STR6## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
17 words
The composition of matter of claim 5 wherein said N.sup.α -alkyl derivative of arginine is N.sup.α -octylarginine.
Claim 9
Dependent Claim
17 words
The composition of matter of claim 5 wherein said N.sup.α -alkyl derivative of arginine is N.sup.α -decylarginine.
Claim 10
Dependent Claim
15 words
The composition of matter of claim 5 wherein said pharmaceutically acceptable carrier is a dentifrice.
Claim 11
Dependent Claim
15 words
The composition of matter of claim 5 wherein said pharmaceutically acceptable carrier is a lozenge.
Claim 12
Dependent Claim
60 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N.sup.α -alkyl derivative of arginine having the formula: ##STR7## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
60 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N.sup.α -alkyl derivative of arginine having the formula: ##STR7## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
15 words
The composition of matter of claim 10 wherein said pharmaceutically acceptable carrier is a mouthrinse.
Claim 15
Dependent Claim
15 words
The composition of matter of claim 10 wherein said pharmaceutically acceptable carrier is a dentifrice.
Claim 16
Dependent Claim
64 words
The composition of matter for oral hygiene to inhibit formation of caries comprising from about 0.05 to about 10% of N.sup.α -alkyl derivative of arginine having the formula: ##STR8## wherein y is an integer of from 6 to 19, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 17
Dependent Claim
64 words
The composition of matter for oral hygiene to inhibit formation of caries comprising from about 0.05 to about 10% of N.sup.α -alkyl derivative of arginine having the formula: ##STR8## wherein y is an integer of from 6 to 19, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 18
Dependent Claim
17 words
The composition of matter of claim 13 wherein said N.sup.α -alkyl derivative of arginine is N.sup.α -octylarginine.
Claim 19
Dependent Claim
17 words
The composition of matter of claim 13 wherein said N.sup.α -alkyl derivative of arginine is N.sup.α -decylarginine.
Claim 20
Independent Claim
54 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity in a pharmaceutically acceptable carrier, an effective amount of an N.sup.α -alkyl derivative of arginine having the formula: ##STR9## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 21
Independent Claim
54 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity in a pharmaceutically acceptable carrier, an effective amount of an N.sup.α -alkyl derivative of arginine having the formula: ##STR9## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 22
Independent Claim
68 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N.sup.α -alkyl derivative of arginine having the formula: ##STR10## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 23
Independent Claim
68 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N.sup.α -alkyl derivative of arginine having the formula: ##STR10## wherein y is an integer of from 6 to 29, or a pharmaceutically acceptable salt thereof.
Claim 24
Independent Claim
73 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising from about 0.05 to about 10% of N.sup.α -alkyl derivative of arginine having the formula: ##STR11## wherein y is an integer of from 6 to 19, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 25
Independent Claim
73 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising from about 0.05 to about 10% of N.sup.α -alkyl derivative of arginine having the formula: ##STR11## wherein y is an integer of from 6 to 19, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-16 | 1988-04-16 | 1988-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-16 | 1992-04-16 | 1992-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-16 | 1996-04-16 | 1996-10-16 | $7700.00 | Window Closed / Lapsed |