Patent US4476307A successfully refreshed from Google Patents.
US4476307A
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Heteroylidene indolone compounds
Assignee: Pfizer Inc
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Filing: 1982-09-20
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Granted: 1984-10-09
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Expires: 2002-09-20
Abstract
Abstract Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neuroleptic agent; or in the treatment of epilepsy. A wider class of substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones, together with 1-phenyl-3-(2-pyrrolidinylidene)-2(1H,3H)-indolones, and homologs thereof, are valuable in the treatment of anxiety.
Inventors
- 👤 Harry R. Howard, Jr.
- 👤 Reinhard Sarges
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 23:54
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/08; A; A61; A61P; A61P25/00; A61P25/08; A61P25/18; A61P25/20; C07C; C07C43/00; C07C43/02; C07C43/20; C07C43/225; C07D209/30; C07D209/32; C07D209/34; C07D209/38
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
103 words
A compound of the formula ##STR8## wherein A 1 and B together are 1,3-propylene, 1,4-butylene or 1,5-pentylene; C is hydrogen, (C 1 -C 2 )alkyl, phenyl or benzyl; W is hydrogen, (C 1 -C 2 )alkyl, (C 1 -C 2 )alkoxy, chloro, or fluoro; and W 1 , X 1 and Y 1 are each independently hydrogen, (C 1 -C 2 )alkyl, (C 1 -C 2 )alkoxy, (C 1 -C 2 )alkylthio, bromo, chloro, fluoro, trifluoromethyl, hydroxy, formyl, carboxamido, (C 1 -C 2 )alkylcarboxamido, di(C 1 -C 2 )alkylcarboxamido, cyano, nitro, amino, (C 1 -C 2 )alkylamino or di(C 1 -C 2 )alkylamino.
Claim 2
Dependent Claim
103 words
A compound of the formula ##STR8## wherein A 1 and B together are 1,3-propylene, 1,4-butylene or 1,5-pentylene; C is hydrogen, (C 1 -C 2 )alkyl, phenyl or benzyl; W is hydrogen, (C 1 -C 2 )alkyl, (C 1 -C 2 )alkoxy, chloro, or fluoro; and W 1 , X 1 and Y 1 are each independently hydrogen, (C 1 -C 2 )alkyl, (C 1 -C 2 )alkoxy, (C 1 -C 2 )alkylthio, bromo, chloro, fluoro, trifluoromethyl, hydroxy, formyl, carboxamido, (C 1 -C 2 )alkylcarboxamido, di(C 1 -C 2 )alkylcarboxamido, cyano, nitro, amino, (C 1 -C 2 )alkylamino or di(C 1 -C 2 )alkylamino.
Claim 3
Dependent Claim
13 words
A compound of claim 1 wherein A 1 and B together are 1,3-propylene.
Claim 4
Dependent Claim
14 words
A compound of claim 2 wherein C is methyl and W 1 is hydrogen.
Claim 5
Dependent Claim
17 words
The compound of claim 3 wherein W and Y 1 are hydrogen and X 1 is 3-methoxy.
Claim 6
Dependent Claim
18 words
The compound of claim 3 wherein W is hydrogen, X 1 is 3-chloro and Y 1 is 4-methoxy.
Claim 7
Dependent Claim
17 words
The compound of claim 3 wherein W and X 1 are hydrogen and Y 1 is 4-methoxy.
Claim 8
Dependent Claim
17 words
The compound of claim 3 wherein W is 6-chloro and X 1 and Y 1 are hydrogen.
Claim 9
Dependent Claim
19 words
A compound of claim 3 wherein W, W 1 and Y 1 are hydrogen and X 1 is 3-chloro.
Claim 10
Dependent Claim
17 words
The compound of claim 7 wherein A 1 and B together are 1,3-propylene and C is benzyl.
Claim 11
Dependent Claim
17 words
The compound of claim 7 wherein A 1 and B together are 1,3-propylene and C is methyl.
Claim 12
Dependent Claim
17 words
The compound of claim 7 wherein A 1 and B together are 1,4-butylene and C is methyl.
References Cited (Backward Citations)
US3506683A
Cited
BE849626A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1987-10-09 | 1988-04-09 | 1988-10-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-09 | 1992-04-09 | 1992-10-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-09 | 1996-04-09 | 1996-10-09 | $7700.00 | Window Closed / Lapsed |