US4474811A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-inflammatory ophthalmic solution and process for preparing the same
Assignee: Kaken Pharmaceutical Co Ltd
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Filing: 1982-08-24
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Granted: 1984-10-02
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Expires: 2002-08-24
Abstract
Abstract An anti-inflammatory ophthalmic solution containing (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) beta -cyclodextrin or gamma -cyclodextrin. The ophthalmic solution makes easy operations conducted for diseases in ophthalmic region, and is useful for early recovery or reduction of inflammation by pre- and post-operative topical instillation thereof or by intraocular perfusion with a perfusate to which the ophthalmic solution is added, or for treatment of inflammatory eye diseases.
Inventors
- 👤 Kiyoshi Masuda
- 👤 Takashi Ikari
- 👤 Takashi Matsuyama
- 👤 Akio Terashima
- 👤 Takao Goto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:22
CPC Classifications
B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K47/00; A61K47/30; A61K47/36; A61K47/40; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
42 words
An anti-inflammatory ophthalmic solution comprising (A) an ophthalmologically anti-inflammatory effective amount of 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) β-cyclodextrin or γ-cyclodextrin in an aqueous medium, the molar ratio of component (A) to component (B) being from 1:0.5 to 1:2.5.
Claim 2
Dependent Claim
42 words
An anti-inflammatory ophthalmic solution comprising (A) an ophthalmologically anti-inflammatory effective amount of 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) β-cyclodextrin or γ-cyclodextrin in an aqueous medium, the molar ratio of component (A) to component (B) being from 1:0.5 to 1:2.5.
Claim 3
Dependent Claim
21 words
The anti-inflammatory ophthalmic solution of claim 1, wherein the concentration of the component (A) is from 0.001 to 2 w/v %.
Claim 4
Dependent Claim
33 words
The anti-inflammatory ophthalmic solution of claim 1, which further contains an ophthalmologically acceptable viscosity-inducing agent in an amount such that the ophthalmic solution has a relative viscosity of from 2 to 30 cP.
Claim 5
Dependent Claim
19 words
The anti-inflammatory ophthalmic solution of claim 1, which is adjusted to pH 5.0 to 8.0 with a buffer agent.
Claim 6
Dependent Claim
22 words
The anti-inflammatory ophthalmic solution of claim 1 wherein component (A) and component (B) are present in the form of an inclusion complex.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-02 | 1988-04-02 | 1988-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-02 | 1992-04-02 | 1992-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-02 | 1996-04-02 | 1996-10-02 | $7700.00 | Window Closed / Lapsed |