Anti-inflammatory composition

Claim 1

A pharmaceutical composition useful for treating inflammation containing (i) a renal vasodilator compound of the formula ##STR5## wherein R is carboxy, a carboxy salt, a carboxy ester of the formula COOR 5 wherein R 5 is C 1-10 alkyl,, or CONHR 6 wherein R 6 is amino or methylsulfonyl; A is a p-phenylene or a m-phenylene or substituted phenylene derivative in which one or two of the phenylene hydrogens is replaced by a methyl or a halo substituent; n is 3 or 4; m is 0, 1, or 2; R 1 is hydrogen, deuterium, or methyl; Z is alkylene or unsaturated alkylene having from 2-3 carbon atoms; R 2 is hydrogen or lower alkanoyl; R 3 is hydrogen or straight chain C 1-3 alkyl; and R 4 is lower straight chain or branched alkyl having from 3-7 carbon atoms, an unsaturated alkyl having from 3-7 carbon atoms, or a substituted lower alkyl selected from polyfluoro alkyl of from 3-7 carbon atoms and lower alkoxy methylene; or R 3 and R 4 taken together with the carbon atom connecting R 3 and R 4 is a cyclic substituent selected from a bridged or unbridged alicyclic ring of from 5-9 carbon atoms or a heterocyclic ring containing sulfur or oxygen and from 5-7 ring-forming carbon atoms. and (ii) inclomethacin wherein the weight ratio i:ii ranges from 1.7:1 to 1:26.