US4474787A
Expired / Lapsed
US
⏱️ 0.0 years remaining
7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof
Assignee: King Pharmaceuticals Inc
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Filing: 1982-02-02
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Granted: 1984-10-02
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Expires: 2002-02-02
Abstract
Abstract There are described compounds of formula I ##STR1## in which an adjacent pair of R 5 , R 6 , R 7 and R 8 form a chain --COCH═CE--O--, and the remainder of R 5 , R 6 , R 7 and R 8 , which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR 1 R 2 in which R 1 and R 2 , which are the same or different, are each hydrogen or alkyl, Rg is hydrogen, alkyl, alkenyl or phenyl-alkyl, and E is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group, and pharmaceutically acceptable derivatives thereof. There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
Inventors
- 👤 Hugh Cairns
- 👤 David Cox
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:53
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/04; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/24
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
66 words
A compound having the formula ##STR16## in which R 6 and R 7 form a chain --COCH═C(COOH)--O--, R 5 and R 8 , which may be the same or different, are sterically compatible substituents selected from hydrogen and alkyl having up to 8 carbon atoms, and R g is hydrogen or alkyl having up to 8 carbon atoms, and pharmaceutically acceptable salts and ethyl esters thereof.
Claim 2
Dependent Claim
66 words
A compound having the formula ##STR16## in which R 6 and R 7 form a chain --COCH═C(COOH)--O--, R 5 and R 8 , which may be the same or different, are sterically compatible substituents selected from hydrogen and alkyl having up to 8 carbon atoms, and R g is hydrogen or alkyl having up to 8 carbon atoms, and pharmaceutically acceptable salts and ethyl esters thereof.
Claim 3
Dependent Claim
28 words
A compound according to claim 1, wherein each of R 5 , R 8 and R g , when they are alkyl, contain up to 4 carbon atoms.
Claim 4
Dependent Claim
22 words
A compound according to claim 1, wherein the --COCH═C(COOH)--O-- chain is bonded with the --O-- end thereof in position R 7 .
Claim 5
Dependent Claim
18 words
A compound according to claim 1, wherein R 5 and R 8 are selected from hydrogen and propyl.
Claim 6
Dependent Claim
11 words
A compound according to claim 1, wherein R g is ethyl.
Claim 7
Dependent Claim
8 words
4,6-Dioxo-1-ethyl-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
8 words
4,6-Dioxo-1-ethyl-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
8 words
4,6-Dioxo-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
8 words
4,6-Dioxo-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
40 words
A pharmaceutical composition suitable for the treatment of a condition involving an antibody antigen reaction or a reflex pathway comprising an effective amount of a compound according to claim 1 in combination with a pharmmaceutically acceptable adjuvant, diluent or carrier.
Claim 12
Dependent Claim
15 words
A composition according to claim 8 comprising less than 80% by weight of active ingredient.
Claim 13
Dependent Claim
23 words
A composition comprising from 0.01 mg to 50 mg of a compound according to claim 1, as active ingredient, in unit dosage form.
Claim 14
Dependent Claim
37 words
A method of treatment of a condition involving an antibody antigen reaction or a reflex pathway, which comprises administering an effective amount of a compound according to claim 1 to an animal suffering from such a condition.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-02 | 1988-04-02 | 1988-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-02 | 1992-04-02 | 1992-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-02 | 1996-04-02 | 1996-10-02 | $7700.00 | Window Closed / Lapsed |