US4117134A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4,5-dihydro-4,5-dioxo-1h-1-benzopyrano (2,3-b)-pyridine-3-carboxylic acids, salts and esters
Assignee: Warner Lambert Co LLC
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Filing: 1978-06-13
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Granted: 1978-09-26
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Expires: 1998-06-13
Abstract
Abstract This invention relates to compounds of the formula ##STR1## wherein R 1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof. The compounds of the invention are active in the prevention of allergic and asthmatic reactions in mammals.
Inventors
- 👤 David T. Connor
- 👤 Maximilian VON Strandtmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 11:53
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/04; C07D311/00; C07D311/02; C07D311/04; C07D311/22
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
40 words
A compound of the formula VII: ##STR8## wherein R 1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof.
Claim 2
Dependent Claim
40 words
A compound of the formula VII: ##STR8## wherein R 1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof.
Claim 3
Dependent Claim
21 words
A compound according to claim 1 wherein R 1 , R 2 and R 3 are each hydrogen or lower alkyl.
Claim 4
Dependent Claim
23 words
A compound according to claim 1 wherein R 1 is hydrogen, and R 2 and R 3 are each hydrogen or lower alkyl.
Claim 5
Dependent Claim
10 words
A compound according to claim 1 which is ethyl 4,5-dihydro-4,5-dioxo-1H-1-benzopyrano[2,3-b]pyridine-3-carboxylate.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 which is 4,5-dihydro-4,5-dioxo-1H-1-benzopyran[2,3-b]pyridine-3-carboxylic acid.
Claim 7
Dependent Claim
10 words
A compound according to claim 1 which is 1-methyl-4,5-dihydro-4,5-dioxo-1H-1-benzopyrano[2,3-b]pyridine-3-carboxylic acid.
Claim 8
Dependent Claim
60 words
A pharmaceutical composition for alleviating allergic manifestations in mammals comprising an effective amount of a compound of the formula VII. ##STR9## wherein R 1 is hydrogen, lower alkyl, hydroxy or lower alkoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof, together with an inert pharmaceutical carrier therefor.
Claim 9
Dependent Claim
60 words
A pharmaceutical composition for alleviating allergic manifestations in mammals comprising an effective amount of a compound of the formula VII. ##STR9## wherein R 1 is hydrogen, lower alkyl, hydroxy or lower alkoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof, together with an inert pharmaceutical carrier therefor.
Claim 10
Independent Claim
60 words
A method of preventing allergic manifestations in mammals in need thereof which comprises the administration of an effective amount of a compound of the formula VII: ##STR10## wherein R 1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof.
Claim 11
Independent Claim
60 words
A method of preventing allergic manifestations in mammals in need thereof which comprises the administration of an effective amount of a compound of the formula VII: ##STR10## wherein R 1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof.
References Cited (Backward Citations)
JPS4720627U
Cited
DE2416519A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-25 | 1982-03-27 | 1982-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-25 | 1986-03-27 | 1986-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-25 | 1990-03-27 | 1990-09-26 | $7700.00 | Window Closed / Lapsed |