Patent US4474757A successfully refreshed from Google Patents.
US4474757A
Expired / Lapsed
US
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Synthetic vaccine and process for producing same
Assignee: Yeda Research and Development Co Ltd
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Filing: 1981-12-29
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Granted: 1984-10-02
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Expires: 2001-12-29
Abstract
Abstract There is provided a synthetic vaccine against influenza virus infections consisting of a synthetic peptide corresponding to a relevant antigenic fragment of the virus, which fragment is attached to a suitable carrier, such as a macromolecule. Effective vaccinations against a plurality of strains can be obtained when the antigenic fragment is one common to such strains. Such synthetic vaccines are produced by synthesizing peptides corresponding to such relevant antigenic fragments and coupling same to a suitable carrier, such as a macromolecule. There is also provided a process for the vaccination of mammals against influenza which comprises applying to said mammals an effective quantity of a vaccine according to the invention.
Inventors
- 👤 Ruth Arnon
- 👤 Michal Shapira
- 👤 Gunhild Muller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:06
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K39/00; A61K39/12; A61K39/145; A61K39/385; A61K2039/555; A61K2039/55511; A61K2039/55566; A61K2039/60; A61K2039/6031; A61K2039/6037; A61K2039/6093; C12; C12N; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16022; C12N2760/16034; C12N2760/16111; C12N2760/16134; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S530/807; Y10S530/82; Y10S530/826; Y10S930/00; Y10S930/01; Y10S930/29
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
81 words
A synthetic vaccine against a plurality of differing influenza virus infections comprising a suitable macromolecular carrier having attached thereto a synthetic peptide corresponding to an antigenic fragment of the hemagglutinin component of an influenza virus, which antigenic fragment is common to a plurality of differing influenza virus strains and capable of eliciting antibodies capable of neutralizing each of said intact differing influenza virus strain, said antigenic fragment being selected from the group of peptides consisting of: Pro-Ser-Thr-Asp-Glu-Glu-Gln-Thr-Ser-Leu-Tyr-Val; Phe-Phe-Ser-Arg-Leu-Asn-Trp-Leu-Tyr-Lys-Ser-Gly-Ser-Thr-Tyr-Pro-Val-Leu; Ser-Lys-Ala-Phe-Ser-Asn-Ala-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-Ser-Leu; and Ala-Ala-Lys-Arg-Gly-Pro-Asp-Ser-Gly-(phenylalanine)-(phenylalanine)-Ser-Arg-Leu-Asp-Tyr-Leu-Thr-Lys-Ser-Gly-Ser-Thr-Thr-Pro-Val-Leu.
Claim 2
Dependent Claim
81 words
A synthetic vaccine against a plurality of differing influenza virus infections comprising a suitable macromolecular carrier having attached thereto a synthetic peptide corresponding to an antigenic fragment of the hemagglutinin component of an influenza virus, which antigenic fragment is common to a plurality of differing influenza virus strains and capable of eliciting antibodies capable of neutralizing each of said intact differing influenza virus strain, said antigenic fragment being selected from the group of peptides consisting of: Pro-Ser-Thr-Asp-Glu-Glu-Gln-Thr-Ser-Leu-Tyr-Val; Phe-Phe-Ser-Arg-Leu-Asn-Trp-Leu-Tyr-Lys-Ser-Gly-Ser-Thr-Tyr-Pro-Val-Leu; Ser-Lys-Ala-Phe-Ser-Asn-Ala-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-Ser-Leu; and Ala-Ala-Lys-Arg-Gly-Pro-Asp-Ser-Gly-(phenylalanine)-(phenylalanine)-Ser-Arg-Leu-Asp-Tyr-Leu-Thr-Lys-Ser-Gly-Ser-Thr-Thr-Pro-Val-Leu.
Claim 3
Dependent Claim
21 words
A synthetic vaccine in accordance with claim 1, wherein said macromolecular carrier is multi-poly-DL-alanyl-poly-L-lysine (A--L), multi-poly-L-propyl-poly-L-lysine (Pro--L), or purified tetanus toxoid.
Claim 4
Dependent Claim
16 words
A synthetic vaccine in accordance with claim 1 wherein said macromolecular carrier is purified tetanus toxoid.
Claim 5
Dependent Claim
23 words
A synthetic vaccine in accordance with claim 1, wherein said synthetic peptide is attached to said macromolecular carrier via 1-ethyl-3-(3'-dimethylaminopropyl) carbodiimide hydrochloride (EDCI).
Claim 6
Dependent Claim
16 words
A synthetic vaccine in accordance with claim 1, wherein said synthetic peptide has the structure Ser-Lys-Ala-Phe-Ser-Asn-Ala-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-Ser-Leu.
Claim 7
Dependent Claim
21 words
A synthetic vaccine in accordance with claim 5, wherein said macromolecular carrier is multi-poly-DL-alanyl-poly-L-lysine (A--L), multi-poly-L-propyl-poly-L-lysine (Pro--L), or purified tetanus toxoid.
Claim 8
Dependent Claim
23 words
A synthetic vaccine in accordance with claim 2, wherein said synthetic peptide is attached to said macromolecular carrier via 1-ethyl-3-(3'-dimethylaminopropyl) carbodiimide hydrochloride (EDCI).
Claim 9
Dependent Claim
12 words
A synthetic vaccine in accordance with claim 1 in unit dosage form.
Claim 10
Dependent Claim
33 words
A process for the vaccination of mammals against each of a plurality of differing influenza virus strains, comprising, administering to said mammal an effective quantity of a vaccine in accordance with claim 1.
Claim 11
Dependent Claim
33 words
A process for the vaccination of mammals against each of a plurality of differing influenza virus strains, comprising, administering to said mammal an effective quantity of a vaccine in accordance with claim 2.
Claim 12
Dependent Claim
33 words
A process for the vaccination of mammals against each of a plurality of differing influenza virus strains, comprising, administrating to said mammal an effective quantity of a vaccine in accordance with claim 5.
Claim 13
Dependent Claim
33 words
A process for the vaccination of mammals against each of a plurality of differing influenza virus strains, comprising, administering to said mammal an effective quantity of a vaccine in accordance with claim 6.
Claim 14
Dependent Claim
33 words
A process for the vaccination of mammals against each of a plurality of differing influenza virus strains, comprising, administering to said mammal an effective quantity of a vaccine in accordance with claim 7.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-02 | 1988-04-02 | 1988-10-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-02 | 1992-04-02 | 1992-10-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-02 | 1996-04-02 | 1996-10-02 | $7700.00 | Window Closed / Lapsed |