3,20-Dioxo-1,4-pregnadiene-17α-ol 17-aromatic heterocycle carboxylates

Claim 1

A 3,20-dioxo-1,4-pregnadiene of the following formula: ##STR3## X is a member selected from the group consisting of hydrogen and halogen having an atomic weight less than 100; Y is a member selected from the group consisting of (H,H) provided X is hydrogen, oxygen, (H,βOH), and (H,β-halogen) provided X is chlorine or bromine, said β-halogen having an atomic weight of less than 100 and being at least as electronegative as X; Z is hydrogen, CH 3 , chlorine, or fluorine; V is an acyl radical of an aromatic heterocyclic carboxylic acid selected from the group consisting of thiophenecarboxylic acid, pyrrolecarboxylic acid and furancarboxylic acid, and methyl and halogen-substituted derivatives thereof; W is a member selected from the group consisting of (H,H); (H, lower alkyl); (H, OV 1 ) wherein V 1 is a member selected from the group consisting of hydrogen and an acyl radical of an acid selected from the group consisting of a hydrocarboncarboxylic acid having up to 12 carbon atoms, benzoic acid substituted by a halogen or methoxy group, retinoic acid, and isonicotinic acid; ═CHT wherein T is a member selected from the group consisting of hydrogen, lower alkyl, fluorine, and chlorine; G is hydrogen, a halogen having an atomic weight less than 100, or OV 2 wherein V 2 is a member selected from the group consisting of hydrogen, an acyl radical of a hydrocarboncarboxylic acid having up to 12 carbon atoms, benzoic acid substituted by a halogen or methoxy group, retinoic acid, isonicotinic acid, and the acid radical of phosphoric acid and mono- and dialkali and alkaline earth metal salts thereof; and the 6-dehydro and 1,2-dihydro analogs of the foregoing.