Patent US4472374A successfully refreshed from Google Patents.
US4472374A
Expired / Lapsed
US
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Veterinary compositions for reducing mammary infections
Assignee: Beecham Group PLC
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Filing: 1982-09-24
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Granted: 1984-09-18
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Expires: 2002-09-24
Abstract
Abstract An intramammary composition containing a siloxane elastomer with incorporated antibacterial agent. The composition is of sufficiently low viscosity to facilitate application to the teat of a cow via the streak canal, and the composition remains sufficiently elastic to enable it to remain in place during the dry period and to allow it to be readily milked-out at the onset of lactation. The composition is useful in reducing mammary infections in cattle during their dry period and is compatible with conventional mastitis treatments at the end of lactation.
Inventors
- 👤 John S. Dowrick
- 👤 Peter Balderstone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 23:05
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0041; A61K47/00; A61K47/30; A61K47/34
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
39 words
A veterinary composition for reducing mammary infections in cattle during their dry period, which composition comprises a catalytically cross-linked siloxane elastomer of sufficiently low viscosity to facilitate application to the mammary gland by injection, contained in an injection means.
Claim 2
Dependent Claim
39 words
A veterinary composition for reducing mammary infections in cattle during their dry period, which composition comprises a catalytically cross-linked siloxane elastomer of sufficiently low viscosity to facilitate application to the mammary gland by injection, contained in an injection means.
Claim 3
Dependent Claim
14 words
A veterinary composition as claimed in claim 1 which also comprises an antibacterial agent.
Claim 4
Dependent Claim
35 words
A veterinary composition as claimed in claim 2, wherein the antibacterial agent is incorporated into the siloxane elastomer, the weight ratio of siloxane elastomer to antibacterial agent being 500 to 1 to 7 to 3.
Claim 5
Dependent Claim
28 words
A veterinary composition as claimed in claim 3, wherein the ratio of siloxane elastomer to incorporated antibacterial agent by weight is 17 to 3 to 7 to 3.
Claim 6
Dependent Claim
25 words
A veterinary composition as claimed in claim 2, in which the composition also comprises an antibacterial agent in the form of a solution or suspension.
Claim 7
Dependent Claim
21 words
A veterinary composition as claimed in claim 2 wherein the antibacterial agent comprises ampicillin trihydrate or benzathine cloxacillin or mixtures thereof.
Claim 8
Dependent Claim
39 words
A veterinary composition as claimed in claim 1, wherein the siloxane elastomer comprises an elastic polymer of silicon containing repeating units of a formula: ##STR2## wherein R is a C 1-6 alkyl, C 1-6 alkenyl or a phenyl group.
Claim 9
Dependent Claim
20 words
A veterinary composition as claimed in claim 1, in dosage unit form, suitable for the treatment of a single teat.
Claim 10
Dependent Claim
20 words
A veterinary composition as claimed in claim 8, wherein the dosage unit comprises 0.1 to 5 ml, of siloxane elastomer.
Claim 11
Dependent Claim
39 words
A method of reducing mammary infections in cattle during their dry period which comprises injecting the teats of cattle with a veterinary composition as claimed in claim 2, in an amount sufficient to seal said teats with said elastomer.
Claim 12
Dependent Claim
39 words
A veterinary composition for reducing mammary infections in cattle during their dry period, which composition comprises an antibacterial agent, and a catalytically cross-linked siloxane elastomer of sufficiently low viscosity to facilitate its application to the mammary gland by injection.
Claim 13
Dependent Claim
39 words
A veterinary composition for reducing mammary infections in cattle during their dry period, which composition comprises an antibacterial agent, and a catalytically cross-linked siloxane elastomer of sufficiently low viscosity to facilitate its application to the mammary gland by injection.
Claim 14
Independent Claim
104 words
A method of reducing infections in cattle during the dry period, which comprises infusing via an infusion means into the teat sinus of a teat of said cattle a first portion of a veterinary composition comprising a catalytically cross-linked siloxane elastomer of sufficiently low viscosity to facilitate such infusion and filling the streak canal of said teat with said elastomer, whereby said teat is sealed, by infusing a second portion of said veterinary composition into the streak canal of said teat while said infusion means is withdrawn out of said teat, said second portion being effective to fill said streak canal with said elastomer.
Claim 15
Independent Claim
104 words
A method of reducing infections in cattle during the dry period, which comprises infusing via an infusion means into the teat sinus of a teat of said cattle a first portion of a veterinary composition comprising a catalytically cross-linked siloxane elastomer of sufficiently low viscosity to facilitate such infusion and filling the streak canal of said teat with said elastomer, whereby said teat is sealed, by infusing a second portion of said veterinary composition into the streak canal of said teat while said infusion means is withdrawn out of said teat, said second portion being effective to fill said streak canal with said elastomer.
Claim 16
Dependent Claim
15 words
The method according to claim 12, wherein said veterinary composition also comprises an antibacterial agent.
Claim 17
Dependent Claim
33 words
The method according to claim 13, wherein the antibacterial agent is incorporated into the siloxane elastomer, the weight ratio of siloxane elastomer to antibacterial agent being 500 to 1 to 7 to 3.
Claim 18
Dependent Claim
19 words
The method according to claim 13, wherein the antibacterial agent comprises ampicillin trihydrate or benzathine cloxacillin or mixtures thereof.
Claim 19
Dependent Claim
37 words
The method according to claim 15, wherein the siloxane elastomer comprises an elastic polymer of silicon containing repeating units of a formula: ##STR3## wherein R is a C 1-6 alkyl, C 1-6 alkenyl or a phenyl group.
Claim 20
Dependent Claim
29 words
The method according to claim 12, wherein the majority of said veterinary composition is infused into said teat sinus and the remainder thereof is infused into said streak canal.
Claim 21
Dependent Claim
29 words
The method according to claim 13, wherein the majority of said veterinary composition is infused into said teat sinus and the remainder thereof is infused into said streak canal.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-18 | 1988-03-19 | 1988-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-18 | 1992-03-19 | 1992-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-18 | 1996-03-19 | 1996-09-18 | $7700.00 | Window Closed / Lapsed |