Patent US4470987A successfully refreshed from Google Patents.
US4470987A
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Process for treatment and prevention of ventricular fibrillation
Assignee: Massachusetts Institute of Technology
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Filing: 1981-05-18
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Granted: 1984-09-11
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Expires: 2001-05-18
Abstract
Abstract The risk of ventricular fibrillation in animals is reduced by administering tyrosine, a tyrosine precursor, threonine or mixtures thereof, either alone or in combination with a substance which is known to reduce the risk of ventricular fibrillation. A novel composition is provided comprising a unit dosage form of tyrosine, a precursor for tyrosine, threonine or mixtures thereof and a substance which is known to reduce the risk of ventricular fibrillation.
Inventors
- 👤 Richard J. Wurtman
- 👤 Bernard Lown
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 21:20
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
90 words
The process for preventing or treating ventricular fibrillation in an animal having a condition associated with ventricular fibrillation which comprises administering to the animal a mixture of (a) a compound selected from the group consisting of tyrosine, phenylalanine, threonine or mixtures thereof and (b) a drug selected from the group consisting of procaine amide, quinidine, propranolol, disopyramide, or pharmaceutically acceptable salts thereof and mixtures thereof in an amount effective to prevent or treat ventricular fibrillation wherein the dosage of (a) is between about 0.5 and about 20 mg/kg body weight.
Claim 2
Dependent Claim
90 words
The process for preventing or treating ventricular fibrillation in an animal having a condition associated with ventricular fibrillation which comprises administering to the animal a mixture of (a) a compound selected from the group consisting of tyrosine, phenylalanine, threonine or mixtures thereof and (b) a drug selected from the group consisting of procaine amide, quinidine, propranolol, disopyramide, or pharmaceutically acceptable salts thereof and mixtures thereof in an amount effective to prevent or treat ventricular fibrillation wherein the dosage of (a) is between about 0.5 and about 20 mg/kg body weight.
Claim 3
Dependent Claim
11 words
The process of claim 1 wherein the animal is a human.
Claim 4
Dependent Claim
15 words
The process of any one of claims 1 or 2 wherein the compound is threonine.
Claim 5
Dependent Claim
15 words
The process of any one of claims 1 or 2 wherein the compound is tyrosine.
Claim 6
Dependent Claim
69 words
A composition comprising a mixture of (a) a compound selected from the group consisting of tyrosine, phenylalanine, threonine or mixtures thereof and (b) a drug selected from the group consisting of procaine amide, quinidine, propranolol, disopyramide or pharmaceutically acceptable salts thereof and mixtures thereof in an amount effective to prevent or treat ventricular fibrillation wherein the dosage of (a) is between about 0.5 and about 20 mg/kg body weight.
Claim 7
Dependent Claim
69 words
A composition comprising a mixture of (a) a compound selected from the group consisting of tyrosine, phenylalanine, threonine or mixtures thereof and (b) a drug selected from the group consisting of procaine amide, quinidine, propranolol, disopyramide or pharmaceutically acceptable salts thereof and mixtures thereof in an amount effective to prevent or treat ventricular fibrillation wherein the dosage of (a) is between about 0.5 and about 20 mg/kg body weight.
Claim 8
Dependent Claim
10 words
The composition of claim 5 wherein the compound is tyrosine.
Claim 9
Dependent Claim
10 words
The composition of claim 5 wherein the compound is threonine.
References Cited (Backward Citations)
US3651237A
Cited
US4230719A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-11 | 1988-03-12 | 1988-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-11 | 1992-03-12 | 1992-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-11 | 1996-03-12 | 1996-09-11 | $7700.00 | Window Closed / Lapsed |