Patent US4469593A successfully refreshed from Google Patents.
US4469593A
Expired / Lapsed
US
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Blood purification apparatus
Assignee: Toyota Central R&D Labs Inc
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Filing: 1983-03-09
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Granted: 1984-09-04
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Expires: 2003-03-09
Abstract
Abstract A blood purification apparatus includes an extracorporeal circulation system, a blood purifier provided in the system for purifying blood by dialysis or filtration through a semipermeable membrane, a circulation blood volume measuring instrument for measuring changes in a circulating blood volume within a patient's body, a control section comprising a memory for storing a program for a pattern of changes in the circulating blood volume during blood purification, the program being matched to the condition of a patient, and a regulator connected to the extracorporeal circulation system and the control section, for controlling the circulating blood volume, the regulator being controlled by the control section on the basis of the circulating blood volume measured during blood purification and the programmed amount. In this apparatus, optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.
Inventors
- 👤 Toshikazu Ishihara
- 👤 Tomoyuki Kitano
- 👤 Kenji Maeda
- 👤 Toru Shinzato
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 11:19
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/34; A61M1/3403; A61M1/3406; A61M1/341; A61M1/342; A61M1/3424; A61M1/3427; A61M1/3437; A61M1/3441; A61M1/3451; A61M1/3455; A61M1/3458; A61M1/36; A61M1/3607; A61M1/3609; A61M1/361; A61M1/3621; A61M1/3669; A61M2205/00; A61M2205/33; A61M2205/3331; A61M2205/3368; A61M2205/3372; A61M2205/50; A61M2205/52; A61M2230/00; A61M2230/20; A61M2230/207
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
152 words
A blood purification apparatus comprising: an extracorporeal circulation system, a blood purifier provided in said system for purifying blood by dialysis or filtration through a semipermeable membrane, a circulating blood volume measuring instrument connected to said extracorporeal circulation system for measuring changes in the circulating blood volume within a patient's body, a control section connected to said circulating blood volume measuring instrument, comprising a memory for storing a program for a pattern of changes in the circulating blood volume during blood purification, said program being matched to the condition of the patient, and a regulator connected to said extracorporeal circulation system and said control section, for controlling the circulating blood volume, said regulator being controlled by said control section on the basis of the circulating blood volume measured during blood purification and the programmed amount, whereby optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.
Claim 2
Dependent Claim
152 words
A blood purification apparatus comprising: an extracorporeal circulation system, a blood purifier provided in said system for purifying blood by dialysis or filtration through a semipermeable membrane, a circulating blood volume measuring instrument connected to said extracorporeal circulation system for measuring changes in the circulating blood volume within a patient's body, a control section connected to said circulating blood volume measuring instrument, comprising a memory for storing a program for a pattern of changes in the circulating blood volume during blood purification, said program being matched to the condition of the patient, and a regulator connected to said extracorporeal circulation system and said control section, for controlling the circulating blood volume, said regulator being controlled by said control section on the basis of the circulating blood volume measured during blood purification and the programmed amount, whereby optimum blood purification is carried out while maintaining the circulating blood volume at a prescribed level.
Claim 3
Dependent Claim
76 words
An apparatus according to claim 1, further comprising a water removal quantity measurement device for measuring the amount of water removed from the patient's body connected to said control section, wherein said control section further comprises a water removal quantity memory for storing a water removal program and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification and the measured quantity of removed water with programmed values.
Claim 4
Dependent Claim
17 words
An apparatus according to claim 1 wherein said regulator comprises a total body fluid volume change regulator.
Claim 5
Dependent Claim
17 words
An apparatus according to claim 2, wherein said regulator comprises a total body fluid volume change regulator.
Claim 6
Dependent Claim
15 words
An apparatus according to claim 1, wherein said regulator comprises a plasma osmotic pressure regulator.
Claim 7
Dependent Claim
85 words
An apparatus according to claim 5, further comprising a plasma osmotic pressure measurement device for substantially measuring the osmotic pressure of the plasma of the patient, connected to said extracorporeal circulation system, and said control section further comprises a plasma osmotic pressure memory for storing a prescribed value of plasma osmotic pressure and controls said regulator on the basis of a comparison of the circulating blood volume measured during purification with the programmed amount and of the measured plasma osmotic pressure with the prescribed value.
Claim 8
Dependent Claim
87 words
An apparatus according to claim 5, further comprising a water removal quantity measurement device for measuring the amount of water removed from the patient's body, wherein said control section further comprises a water removal quantity memory for storing a water removal program, and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification with the programmed amount, of the measured plasma osmotic pressure with the prescribed value, and of the measured amount of removed water with the programmed amount.
Claim 9
Dependent Claim
29 words
An apparatus according to claim 5, wherein said plasma osmotic pressure regulator comprises a means for controlling the infusing rate of osmolal solution to control the plasma ocmotic pressure.
Claim 10
Dependent Claim
22 words
An apparatus according to claim 5, wherein said plasma osmotic pressure regulator comprises a means for varying the electrolytic concentration of plasma.
Claim 11
Dependent Claim
24 words
An apparatus according to claim 6, wherein said plasma osmotic pressure mmeasurement device comprises a means for measuring the electrolytic concentration of the plasma.
Claim 12
Dependent Claim
30 words
An apparatus according to claim 10, wherein said plasma osmotic pressure measurement device comprises at least one ion electrode for measuring the concentration of a specific ion in the plasma.
Claim 13
Dependent Claim
28 words
An apparatus according to claim 10, wherein said plasma osmotic pressure measurement device comprises a means for measuring the electrolytic concentration of the plasma from its electrical resistivity.
Claim 14
Dependent Claim
19 words
An apparatus according to claim 3, wherein said total body fluid volume change regulator comprises a water removal regulator.
Claim 15
Dependent Claim
31 words
An apparatus according to claim 1, wherein said circulating blood volume measuring instrument is a hematocrit measuring instrument which detects changes in the circulating blood volume as changes in the hematocrit.
Claim 16
Dependent Claim
51 words
An apparatus according to claim 14, wherein said hematocrit measuring instrument comprises a resistivity measurement device for measuring the electrical resistivity of the blood in said extracorporeal circulation system, a temperature compensator for compensating the measured resistivity for temperature, and an arithmetic circuit for calculating the hematocrit from the electrical resistivity.
Claim 17
Dependent Claim
108 words
An apparatus according to claim 14, wherein said hematocrit measuring instrument comprises a resistivity measuring device for measuring the electrical resistivity of the blood in said extracorporeal circulation system, a temperature compensator for compensating the measured resistivity for temperature and an arithmetic circuit for calculating the hematocrit from the electrical resistivity, and the resistivity measurement device has a measurement cell including at least one pair of electrodes provided in an insulative pipe communicating with said extracorporeal circulation system at positions symmetrically opposed with respect to the axis of thee insulative pipe and separated from each other by a prescribed distance in the axial direction of said insulative pipe.
Claim 18
Dependent Claim
81 words
An apparatus according to claim 14, wherein said hematocrit measuring instrument comprises a resistivity measuring device for measuring the electrical resistivity of the blood in said extracorporeal circulation system and electrical resistivity of the plasma component of the blood, temperature compensators for compensating the measured resistivity for temperature and an arithmetic circuit for calculating the hematocrit from the electrical resistivity, and the hematocrit is calculated from both the electrical resistivity of the blood and the electrical resistivity of the plasma component.
Claim 19
Dependent Claim
51 words
An apparatus according to claim 16, wherein said resistivity measurement device is further provided with a measurement cell for measuring the electrical resistivity of the plasma component of the blood, and the hematocrit is calculated from both the electrical resistivity of the blood and the electrical resistivity of the plasma component.
Claim 20
Dependent Claim
46 words
An apparatus according to claim 17, wherein a filter is provided for ultrafiltrating a portion of the plasma from said extracorporeal circulation system and the measurement cell for measuring the electrical resistivity of the plasma component is provided in a waste filtrate path of said filter.
Claim 21
Dependent Claim
46 words
An apparatus according to claim 18, wherein a filter is provided for ultrafiltrating a portion of the plasma from said extracorporeal circulation system and the measurement cell for measuring the electrical resistivity of the plasma component is provided in a waste filtrate path of said filter.
Claim 22
Dependent Claim
166 words
An apparatus according to claim 20, further comprising: a water removal quantity measurement device for measuring the amount of water removed from the patient's body, connected to said control section, and a plasma osmotic pressure measurement device for substantially measuring the osmotic pressure of the plasma of the patient, connected to said extracorporeal circulation system and said control section, said resistivity measurement device having a measurement cell including two pairs of electrodes, wherein said regulator comprises a total body fluid volume change regulator and a plasma osmotic pressure regulator, and said control section further comprises a water removal quantity memory for storing a water removal program, and a plasma osmotic pressure memory for storing a prescribed value of plasma osmotic pressure and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification with the programmed amount, of the measured plasma osmotic pressure with the prescribed value, and of the measured amount of removed water with the programmed amount.
Claim 23
Dependent Claim
23 words
An apparatus according to claim 1, wherein said regulator comprises a total body fluid volume change regulator and a plasma osmotic pressure regulator.
Claim 24
Dependent Claim
86 words
An apparatus according to claim 22, further comprising a plasma osmotic pressure measurement device for substantially measuring the osmotic pressure of the plasma of the patient, connected to said extracorporeal circulation system, and said control section further comprises a plasma osmotic pressure memory for storing a prescribed value of plasma osmotic pressure and controls said regulator on the basis of a comparison of the circulating blood volume measured during blood purification with the programmed amount and of the measured plasma osmotic pressure with the prescribed value.
Claim 25
Dependent Claim
27 words
An apparatus according to claim 3, wherein said total body fluid volume change regulator comprises a means for infusing a replacement fluid into said extracorporeal circulation system.
Claim 26
Dependent Claim
20 words
An apparatus according to claim 16, wherein said resistivity measurement device has a measurement cell including two pairs of electrodes.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-04 | 1988-03-05 | 1988-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-04 | 1992-03-05 | 1992-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-04 | 1996-03-05 | 1996-09-04 | $7700.00 | Window Closed / Lapsed |