US4468401A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of blocking peripheral norepinephrine release
Assignee: Eli Lilly and Co
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Filing: 1982-11-03
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Granted: 1984-08-28
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Expires: 2002-11-03
Abstract
Abstract Trans-4aR-5-n-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H(and 2H)pyrazolo[3,4-g]quinoline and pharamceutically-acceptable salts thereof, blocks norepinephrine release from peripheral sympathetic nerve terminals that innervate arterial muscle fibers in hypertensive mammals to reduce blood pressure.
Inventors
- 👤 Richard A. Hahn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 21:41
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
52 words
The method of blocking norepinephrine release from peripheral sympathetic nerve terminals that innervate arterial muscle fibers in mammals which comprises administering to a mammal having an elevated blood pressure an effective dose of trans-4aR-5-n-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H(and 2H)pyrazolo[3,4-g]quinoline or a pharmaceutically acceptable salt thereof, thereby blocking said norepinephrine release and reducing said elevated blood pressure.
Claim 2
Independent Claim
52 words
The method of blocking norepinephrine release from peripheral sympathetic nerve terminals that innervate arterial muscle fibers in mammals which comprises administering to a mammal having an elevated blood pressure an effective dose of trans-4aR-5-n-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H(and 2H)pyrazolo[3,4-g]quinoline or a pharmaceutically acceptable salt thereof, thereby blocking said norepinephrine release and reducing said elevated blood pressure.
Claim 3
Dependent Claim
13 words
A method according to claim 1 in which the D-(-)-S-tartrate salt is employed.
Claim 4
Dependent Claim
13 words
A method according to claim 1 in which the hydrochloride salt is employed.
Claim 5
Dependent Claim
18 words
A method according to claim 1 in which from 0.1 to 15 mg./kg./day of drug are administered orally.
References Cited (Backward Citations)
US4298611A
Cited
US4198415A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-28 | 1988-02-27 | 1988-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-28 | 1992-02-27 | 1992-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-28 | 1996-02-27 | 1996-08-28 | $7700.00 | Window Closed / Lapsed |