Patent US4466957A successfully refreshed from Google Patents.
US4466957A
Expired / Lapsed
US
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Vaccine adjuvants
Assignee: Wyeth LLC
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Filing: 1982-02-25
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Granted: 1984-08-21
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Expires: 2002-02-25
Abstract
Abstract There are disclosed mammalian vaccine compositions comprising an inactivated whole or subunit vaccine or toxoid and an adjuvant having the formula ##STR1## wherein R is hydrogen or lower alkyl, R 1 is hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halo, R 2 is hydrogen, chloro or nitro, n is 1 or 2 and pharmaceutically acceptable salts thereof.
Inventors
- 👤 Richard N. Hjorth
- 👤 Bobby O. Moore
- 👤 Norman H. Grant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 00:08
CPC Classifications
C; C07; C07D; C07D513/00; C07D513/02; C07D513/04; A; A61; A61K; A61K39/00; A61K39/39
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
73 words
A mammalian vaccine composition comprising an inactivated whole or subunit virus vaccine and an effective amount of an adjuvant having the formula ##STR3## wherein R is hydrogen or 1 to 6 carbon atom lower alkyl, R 1 is hydrogen, 1 to 6 carbon atom lower alkyl, 1 to 6 carbon atom lower alkoxy, trifluoromethyl or halo, R 2 is hydrogen, chloro or nitro, n is 1 or 2 and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
73 words
A mammalian vaccine composition comprising an inactivated whole or subunit virus vaccine and an effective amount of an adjuvant having the formula ##STR3## wherein R is hydrogen or 1 to 6 carbon atom lower alkyl, R 1 is hydrogen, 1 to 6 carbon atom lower alkyl, 1 to 6 carbon atom lower alkoxy, trifluoromethyl or halo, R 2 is hydrogen, chloro or nitro, n is 1 or 2 and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
20 words
The composition of claim 1 wherein said vaccine is inactivated whole equine herpesvirus 1 and said adjuvant is 3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid.
Claim 4
Dependent Claim
18 words
The composition of claim 1 wherein said vaccine is subunit influenza A and said adjuvant is 3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-21 | 1988-02-20 | 1988-08-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-21 | 1992-02-20 | 1992-08-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-21 | 1996-02-20 | 1996-08-21 | $7700.00 | Window Closed / Lapsed |