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US4464165A
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Material and method for removing immunoglobulins from whole blood
Assignee: EMD Millipore Corp
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Filing: 1983-10-05
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Granted: 1984-08-07
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Expires: 2003-10-05
Abstract
Abstract An immunoadsorbent material comprising inactivated, protein-A bearing Staphlococcus aureus immobilized in a polymeric matrix is used to remove IgG immunoglobulins and immune complexes from whole blood.
Inventors
- 👤 John K. Pollard, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:53
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; C07K16/065; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61M; A61M1/00; A61M1/36; A61M1/3679; C12; C12N; C12N11/00; C12N11/02; C12N11/04; C12N11/08; C12N11/082; C12N11/087; C12N11/10
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
55 words
A method of treating whole blood to remove IgG immunoglobulins and immune complexes, which method comprises contacting said blood with an immunoadsorbent material comprising inactivated, protein A-bearing Staphlococcus aureus bacteria immobilized in a polymeric matrix said material being in the form of gel like beads having an average diameter ranging from 100 to 1000 microns.
Claim 2
Independent Claim
55 words
A method of treating whole blood to remove IgG immunoglobulins and immune complexes, which method comprises contacting said blood with an immunoadsorbent material comprising inactivated, protein A-bearing Staphlococcus aureus bacteria immobilized in a polymeric matrix said material being in the form of gel like beads having an average diameter ranging from 100 to 1000 microns.
Claim 3
Dependent Claim
23 words
A method according to claim 1 wherein said polymeric matrix is selected from the group consisting of agarose, chitosan, polyacrylamide and polyacrylamide derivatives.
Claim 4
Dependent Claim
12 words
A method according to claim 2 wherein said polymeric matrix is agarose.
Claim 5
Dependent Claim
22 words
A method according to claim 1 wherein said blood is contacted using column chromatography that employs the immunoadsorbent as the solid phase.
Claim 6
Independent Claim
77 words
A method of retarding the growth of neoplasts in subject mammals suffering from same, which method comprises: a. contacting the blood of said subjects in an extra-corporeal circulating system with an immunoadsorbent material comprising inactivated, protein A-bearing Staphlococcus aureus bacteria immobilized in a polymeric matrix said material being in the form of gel like beads having an average diameter ranging from 100 to 1000 microns and b. transfusing said subjects contacted blood back into the host subject.
Claim 7
Independent Claim
77 words
A method of retarding the growth of neoplasts in subject mammals suffering from same, which method comprises: a. contacting the blood of said subjects in an extra-corporeal circulating system with an immunoadsorbent material comprising inactivated, protein A-bearing Staphlococcus aureus bacteria immobilized in a polymeric matrix said material being in the form of gel like beads having an average diameter ranging from 100 to 1000 microns and b. transfusing said subjects contacted blood back into the host subject.
Claim 8
Dependent Claim
23 words
A method according to claim 5 wherein said polymeric matrix is selected from the group consisting of agarose, chitosan, polyacrylamide and polyacrylamide derivatives.
Claim 9
Dependent Claim
12 words
A method according to claim 6 wherein said polymeric matrix is agarose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-08-07 | 1988-02-06 | 1988-08-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-08-07 | 1992-02-06 | 1992-08-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-08-07 | 1996-02-06 | 1996-08-07 | $7700.00 | Window Closed / Lapsed |