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US4463098A
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Hemoglobin marker of alcoholism
Assignee: Albert Einstein College of Medicine
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Filing: 1983-10-03
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Granted: 1984-07-31
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Expires: 2003-10-03
Abstract
Abstract An in vitro method for identifying alcoholism and alcohol abuse in humans is disclosed which comprises the isolation and measurement of a unique and stable form of glycosylated hemoglobin.
Inventors
- 👤 Henry D. Hoberman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:28
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; G01N33/721; G01N33/723
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
126 words
A method for detecting and measuring chronic alcohol consumption constituting alcohol abuse in a human patient comprising: a. obtaining a human blood sample from said patient; b. isolating a fraction of said blood sample which contains glycosylated hemoglobins; c. measuring the amount of said glycosylated hemoglobins as a percentage of the total amount of hemoglobin in said sample; d. providing a measurement of the amount of glycosylated hemoglobins in a blood sample of a known alcohol abuser, the measured amount of the glycosylated hemoglobins of said abuser being more than about 6% of the total hemoglobin in said blood sample of the abuser; and e. comparing the measurements of steps (c) and (d) whereby a comparison of said measurements determines the alcohol abuse of said patient.
Claim 2
Independent Claim
126 words
A method for detecting and measuring chronic alcohol consumption constituting alcohol abuse in a human patient comprising: a. obtaining a human blood sample from said patient; b. isolating a fraction of said blood sample which contains glycosylated hemoglobins; c. measuring the amount of said glycosylated hemoglobins as a percentage of the total amount of hemoglobin in said sample; d. providing a measurement of the amount of glycosylated hemoglobins in a blood sample of a known alcohol abuser, the measured amount of the glycosylated hemoglobins of said abuser being more than about 6% of the total hemoglobin in said blood sample of the abuser; and e. comparing the measurements of steps (c) and (d) whereby a comparison of said measurements determines the alcohol abuse of said patient.
Claim 3
Dependent Claim
13 words
The method of claim 1, wherein the patient's blood sample comprises anticoagulated blood.
Claim 4
Dependent Claim
40 words
Method of claim 1, wherein step (b) thereof further comprises: (i) exposing the red blood cells of step (i) hereof to osmotic shock, whereby a hemolysate is prepared; and (ii) separating the hemoglobin adducts of step (i) hereof by chromatography.
Claim 5
Dependent Claim
17 words
The method of claim 1, wherein the measurements of step (c) are performed by a colorimetric assay.
Claim 6
Dependent Claim
13 words
The method of claim 4, wherein the assay is performed at 421 nm.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-31 | 1988-01-30 | 1988-07-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-31 | 1992-01-30 | 1992-07-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-31 | 1996-01-30 | 1996-07-31 | $7700.00 | Window Closed / Lapsed |