US4463007A
Expired / Lapsed
US
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Triazoloquinazolinones, and compositions and methods for treating allergic disorders with them
Assignee: BASF SE
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Filing: 1982-11-15
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Granted: 1984-07-31
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Expires: 2002-11-15
Abstract
Abstract 1,2,4-Triazolo[1,5-c]-quinazolinones of the general formula I ##STR1## and their pharmaceutically tolerated salts, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful drugs in the treatment of allergic disorders.
Inventors
- 👤 Rainer Schlecker
- 👤 Ludwig Friedrich
- 👤 Dieter Lenke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 17:26
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; A; A61; A61P; A61P37/00; A61P37/08; C07D239/00; C07D239/70; C07D239/72; C07D239/95; C07D491/00; C07D491/02; C07D491/04; C07D491/12; C07D491/14
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
249 words
A compound of the formula I ##STR12## where X is carboxyl which may be in the form of a salt with a physiologically tolerated amine or metal cation, or is ##STR13## where R 4 is alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 8 ring carbon atoms, benzyl, or --(CH 2 ) n --O--R 5 or ##STR14## where n is an integer from 2 to 4 and R 5 and R 6 are each alkyl of 1 to 3 carbon atoms, or X is hydroxymethyl, nitrile, tetrazolyl, carbonylaminotetrazolyl or carbamyl, and R 1 and R 2 are identical or different and are each hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 5 carbon atoms, trifluoromethyl, nitro, amino, an alkyl, monoalkylamino or dialkylamino group where alkyl is of 1 to 5 carbon atoms, alkoxy where alkyl is of 1 to 6 carbon atoms, or an alkylthio, alkylsulfenyl, alkylsulfonyl or dialkylaminosulfonyl radical where alkyl is of 1 to 6 carbon atoms, or R 1 and R 2 together form an alkylenedioxy group --O--(CH 2 ) n --O-- where n is 1 or 2, or an alkylene group --(CH 2 ) n -- where n is 3, 4 or 5, and R 3 is hydrogen, alkyl which is of 1 to 7 carbon atoms and may or may not be interrupted by 1 or 2 oxygen atoms, alkenyl of 2 to 7 carbon atoms or aralkyl of 7 to 10 carbon atoms, and its physiologically tolerated salts with acids.
Claim 2
Dependent Claim
249 words
A compound of the formula I ##STR12## where X is carboxyl which may be in the form of a salt with a physiologically tolerated amine or metal cation, or is ##STR13## where R 4 is alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 8 ring carbon atoms, benzyl, or --(CH 2 ) n --O--R 5 or ##STR14## where n is an integer from 2 to 4 and R 5 and R 6 are each alkyl of 1 to 3 carbon atoms, or X is hydroxymethyl, nitrile, tetrazolyl, carbonylaminotetrazolyl or carbamyl, and R 1 and R 2 are identical or different and are each hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 5 carbon atoms, trifluoromethyl, nitro, amino, an alkyl, monoalkylamino or dialkylamino group where alkyl is of 1 to 5 carbon atoms, alkoxy where alkyl is of 1 to 6 carbon atoms, or an alkylthio, alkylsulfenyl, alkylsulfonyl or dialkylaminosulfonyl radical where alkyl is of 1 to 6 carbon atoms, or R 1 and R 2 together form an alkylenedioxy group --O--(CH 2 ) n --O-- where n is 1 or 2, or an alkylene group --(CH 2 ) n -- where n is 3, 4 or 5, and R 3 is hydrogen, alkyl which is of 1 to 7 carbon atoms and may or may not be interrupted by 1 or 2 oxygen atoms, alkenyl of 2 to 7 carbon atoms or aralkyl of 7 to 10 carbon atoms, and its physiologically tolerated salts with acids.
Claim 3
Dependent Claim
63 words
A compound of the formula I as claimed in claim 1, wherein X is ##STR15## where R 4 is alkyl of 1 to 4 carbon atoms, R 1 and R 2 , which may be identical or different, are each hydrogen, fluorine, chlorine, bromine or alkyl of 1 to 3 carbon atoms and R 3 is alkyl of 1 to 4 carbon atoms.
Claim 4
Dependent Claim
33 words
A compound of the formula I as claimed in claim 1, wherein X is carboethoxy, R 1 and R 2 are each hydrogen, chlorine or methyl and R 3 is methyl or ethyl.
Claim 5
Dependent Claim
10 words
Ethyl 6-ethyl-9-methyl-1,2,4-triazolo[1,5-c]quinazolin-5-one-2-carboxylate and its physiologically tolerated addition salts with acids.
Claim 6
Dependent Claim
10 words
Ethyl 6-ethyl-9-methyl-1,2,4-triazolo[1,5-c]quinazolin-5-one-2-carboxylate and its physiologically tolerated addition salts with acids.
Claim 7
Dependent Claim
10 words
Ethyl 6-methyl-1,2,4-triazolo[1,5-c]quinazolin-5-one-2-carboxylate and its physiologically tolerated addition salts with acids.
Claim 8
Dependent Claim
10 words
Ethyl 6-methyl-1,2,4-triazolo[1,5-c]quinazolin-5-one-2-carboxylate and its physiologically tolerated addition salts with acids.
Claim 9
Dependent Claim
31 words
A therapeutic composition for treating allergic disorders which comprises: a pharmaceutically acceptable carrier and an effective amount of a compound of the formula I of claim 1 as the active agent.
Claim 10
Dependent Claim
27 words
A therapeutic composition for treating allergic disorders which comprises: a pharmaceutically acceptable carrier and an effective amount of the compound of claim 4 as the active agent.
Claim 11
Dependent Claim
27 words
A therapeutic composition for treating allergic disorders which comprises: a pharmaceutically acceptable carrier and an effective amount of the compound of claim 5 as the active agent.
Claim 12
Dependent Claim
34 words
A process for treating allergic disorders which comprises: administering orally, parenterally or by inhalation a composition as set forth in claim 6 in individual doses containing from 0.1 to 100 mg of active agent.
Claim 13
Dependent Claim
33 words
A process for treating allergic disorders which comprises: administering orally, parenterally or by inhalation the composition set forth in claim 7 in individual doses containing from 0.1 to 100 mg of active agent.
Claim 14
Dependent Claim
32 words
A process for treating allergic disorders which comprises: administering orally, parenterally or by inhalation the composition set forth in claim 8 in individual doses containing 0.1 to 100 mg of active agent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-31 | 1988-01-30 | 1988-07-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-31 | 1992-01-30 | 1992-07-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-31 | 1996-01-30 | 1996-07-31 | $7700.00 | Window Closed / Lapsed |