US4128644A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pyrazolo(1,5-c)quinazoline derivatives and related compounds
Assignee: ER Squibb and Sons LLC
•
Filing: 1977-07-29
•
Granted: 1978-12-05
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Expires: 1997-07-29
Abstract
Abstract Compounds are provided having the structure ##STR1## wherein R 1 is hydrogen, alkyl of 1-3 carbons, phenyl optionally substituted by R 4 ; R 2 is cyano; ##STR2## (wherein Z is a single bond or ##STR3## X is O or S); ##STR4## (wherein R 9 is hydrogen or alkyl, Q is CH or N); ##STR5## wherein R 6 is amino, alkylamino, dialkylamino, haloalkyl or ##STR6## and R 4 and R 5 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, substituted benzyloxy, hydroxy, halogen (Cl, Br and F), nitro and trifluoromethyl; and R 7 , R 8 , m and n are defined hereinafter.
Inventors
- 👤 B. Richard Vogt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:12
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
25 words
A compound of the structure ##STR231## wherein R 1 represents hydrogen, lower alkyl, phenyl, or phenyl substituted with mono-lower alkyl, di-lower alkyl, or monohalo, ##STR232##
Claim 2
Dependent Claim
25 words
A compound of the structure ##STR231## wherein R 1 represents hydrogen, lower alkyl, phenyl, or phenyl substituted with mono-lower alkyl, di-lower alkyl, or monohalo, ##STR232##
Claim 3
Dependent Claim
65 words
R 3 is hydrogen, lower alkyl, benzyl, phenyl or phenyl substituted by a single substituent selected from the group consisting of lower alkyl, halo, trifluoromethyl or lower alkoxy; R 4 and R 5 may be the same or different and are hydrogen, lower alkyl, lower alkoxy, hydroxy, lower alkanoyloxy, ##STR233## (X 1 is hydrogen, lower alkoxy, or NO 2 ); and physiologically acceptable salts thereof.
Claim 4
Dependent Claim
65 words
R 3 is hydrogen, lower alkyl, benzyl, phenyl or phenyl substituted by a single substituent selected from the group consisting of lower alkyl, halo, trifluoromethyl or lower alkoxy; R 4 and R 5 may be the same or different and are hydrogen, lower alkyl, lower alkoxy, hydroxy, lower alkanoyloxy, ##STR233## (X 1 is hydrogen, lower alkoxy, or NO 2 ); and physiologically acceptable salts thereof.
Claim 5
Dependent Claim
16 words
The compound of claim 1 wherein R 3 , R 4 and R 5 are hydrogen.
Claim 6
Dependent Claim
11 words
The compound of claim 1 wherein R 3 is lower alkyl.
Claim 7
Dependent Claim
10 words
The compound of claim 1 wherein R 3 is benzyl.
Claim 8
Dependent Claim
10 words
The compound of claim 1 wherein R 3 is phenyl.
Claim 9
Dependent Claim
14 words
The compound of claim 1 wherein R 4 and R 5 are lower alkyl.
Claim 10
Dependent Claim
11 words
The compound of claim 1 wherein R 4 is lower alkyl.
Claim 11
Dependent Claim
11 words
The compound of claim 1 wherein R 4 is lower alkoxy.
Claim 12
Dependent Claim
10 words
The compound of claim 1 wherein R 4 is hydroxy.
Claim 13
Dependent Claim
11 words
The compound of claim 1 wherein R 4 is lower alkanoyloxy.
Claim 14
Dependent Claim
10 words
The compound of claim 1 wherein R 4 is ##STR234##
Claim 15
Dependent Claim
9 words
The compound of claim 1 having the name 2-(1H-tetrazol-5-yl)pyrazolo[1,5-c]quinazolin-5(6H)-one.
Claim 16
Dependent Claim
27 words
A pharmaceutical composition for use in treating allergic conditions comprising an effective amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 17
Dependent Claim
26 words
A method for treating allergic conditions in mammals, which comprises administering to the mammalian host a therapeutic amount of a compound as defined in claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-04 | 1982-06-05 | 1982-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-04 | 1986-06-05 | 1986-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-04 | 1990-06-05 | 1990-12-05 | $7700.00 | Window Closed / Lapsed |