US4461757A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dimethylaminomethylenated anti-herpes compounds
Assignee: Syntex USA LLC
•
Filing: 1983-02-23
•
Granted: 1984-07-24
•
Expires: 2003-02-23
Abstract
Abstract 2-(N,N-dialkylaminomethylene)-9-[[2-hydroxy-1-(hydroxymethyl)-ethoxy]m ethyl]guanine either alone or in admixture with interferon is active in treatment of herpes simplex type 1 viral infections.
Inventors
- 👤 Kelvin K. Ogilvie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:58
CPC Classifications
C; C07; C07D; C07D473/00; A; A61; A61K; A61K31/00; A61K31/66; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/212; A61P; A61P31/00; A61P31/12; A61P31/20; A61P31/22
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
28 words
The compound 2-(N,N-dialkylaminomethylene)-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine of the formula: ##STR4## and its pharmaceutically acceptable salts wherein R and R' each represent an independently selected lower alkyl group of 1-4 carbon atoms.
Claim 2
Dependent Claim
28 words
The compound 2-(N,N-dialkylaminomethylene)-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine of the formula: ##STR4## and its pharmaceutically acceptable salts wherein R and R' each represent an independently selected lower alkyl group of 1-4 carbon atoms.
Claim 3
Dependent Claim
11 words
The compound of claim 1 wherein R and R' are methyl.
Claim 4
Dependent Claim
42 words
A pharmaceutical composition active in combatting herpes virus type 1 infections and consisting essentially of an effective amount of the compound of formula I as given in claim 1 or a pharmaceutically acceptable salt thereof, in admixture with a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
3 words
The compound 2-(N,N-dialkylaminomethylene)-9-[[2-[hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine.
Claim 6
Dependent Claim
3 words
The compound 2-(N,N-dialkylaminomethylene)-9-[[2-[hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine.
Claim 7
Dependent Claim
60 words
A pharmaceutical composition active in combatting herpes simplex virus type 1 infections and consisting essentially of a first drug which is 2-(N,N-dialkylaminomethylene)-9-[[2-hydroxy-1-(hydroxy methyl)ethoxy]methyl]guanine of the formula given in claim 1 or a pharmaceutically acceptable salt thereof, and a second drug which is selected from the group consisting of interferon, phosphonoformic acid and its salts, and phosphonoacetic acid and its salts.
Claim 8
Dependent Claim
11 words
The composition of claim 5 wherein said first drug is 2-(N,N-dimethylaminomethylene)-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine.
Claim 9
Dependent Claim
17 words
The composition of claim 6 wherein the second drug is interferon, interferon α or a mixture thereof.
Claim 10
Dependent Claim
16 words
The composition of claim 6 wherein the second drug is phosphonoformic acid or a salt thereof.
Claim 11
Dependent Claim
16 words
The composition of claim 15 wherein the second drug is phosphonoacetic acid or a salt thereof.
Claim 12
Independent Claim
41 words
A method of treating viral infections which comprises administering to virally infected viable mammalian cells an effective amount of 2-(N,N-dialkylaminomethylene)-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine or a pharmaceutically acceptable salt thereof, wherein each alkyl group is independently selected from lower alkyl groups of 1-4 carbon atoms.
Claim 13
Independent Claim
41 words
A method of treating viral infections which comprises administering to virally infected viable mammalian cells an effective amount of 2-(N,N-dialkylaminomethylene)-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine or a pharmaceutically acceptable salt thereof, wherein each alkyl group is independently selected from lower alkyl groups of 1-4 carbon atoms.
References Cited (Backward Citations)
US4323573A
Cited
US4347360A
Cited
US4347360B1
Cited
US4355032A
Cited
US4355032B1
Cited
US4355032B2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-24 | 1988-01-23 | 1988-07-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-24 | 1992-01-23 | 1992-07-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-24 | 1996-01-23 | 1996-07-24 | $7700.00 | Window Closed / Lapsed |