US4347360A
Expired / Lapsed
US
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Ring open nucleoside analogues
Assignee: Syntex USA LLC
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Filing: 1980-09-16
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Granted: 1982-08-31
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Expires: 2000-09-16
Abstract
Abstract Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups and the like, and B is a base such as adenine, have been shown to exhibit anti-viral and other biological activities at non-toxic levels. Also provided are phosphate-linked dinucleotide compounds of similar structures.
Inventors
- 👤 Kelvin K. Ogilvie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 21:15
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/47; A; A61; A61P; A61P31/00; A61P31/12; C07D239/52; C07D239/54; C07D239/545; C07D239/553; C07D251/00; C07D251/02; C07D251/12; C07D251/14; C07D251/16; C07D473/00; C07D473/02; C07D473/18; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; C07F9/00; C07F9/02; C07F9/547; C07F9/645; C07F9/6509; C07F9/6512; C07F9/6561; C07F9/65616; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
41 words
Compounds of the general formula: ##STR10## wherein R and R' are independently selected from hydrogen, and lower alkyl-substituted silyl, and B represents an unsubstituted adenine or guanine group linked to the side group shown in formula (I) above at its 9-position.
Claim 2
Dependent Claim
41 words
Compounds of the general formula: ##STR10## wherein R and R' are independently selected from hydrogen, and lower alkyl-substituted silyl, and B represents an unsubstituted adenine or guanine group linked to the side group shown in formula (I) above at its 9-position.
Claim 3
Dependent Claim
10 words
Compounds according to claim 1 in which B represents adenine.
Claim 4
Dependent Claim
18 words
Compounds according to claim 2 in which R and R' are independently selected from hydrogen and tertiary butyldimethylsilyl.
Claim 5
Dependent Claim
13 words
A compound according to claim 3 wherein both R and R' are hydrogen.
Claim 6
Dependent Claim
14 words
A compound according to claim 3 wherein R is tert.butyldimethylsilyl and R' is hydrogen.
Claim 7
Dependent Claim
13 words
A compound according to claim 3 wherein both R and R' are tert.butyldimethylsilyl.
References Cited (Backward Citations)
US4199574A
Cited
US4158056A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-30 | 1986-03-01 | 1986-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-30 | 1990-03-01 | 1990-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-30 | 1994-03-01 | 1994-08-31 | $7700.00 | Window Closed / Lapsed |