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US4460591A
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8,10-Dideazaminopterins
Assignee: SRI International Inc
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Filing: 1982-08-26
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Granted: 1984-07-17
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Expires: 2002-08-26
Abstract
Abstract 8,10-Dideazaminopterins of the formula <IMAGE> where R is hydrogen or alkyl of 1 to about 8 carbon atoms and their carboxylate and acid addition salts are described. These compounds exhibit antineoplastic activity that is similar to but more effective than methotrexate.
Inventors
- 👤 Joseph I. DeGraw
- 👤 Lawrence F. Kelly
- 👤 Francis M. Sirotnak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 19:11
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
25 words
A compound of the formula ##STR6## where R is a hydrogen or alkyl of 1 to about 8 carbon atoms, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
25 words
A compound of the formula ##STR6## where R is a hydrogen or alkyl of 1 to about 8 carbon atoms, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
13 words
The compound of claim 1 wherein R is hydrogen, methyl, propyl, or amyl.
Claim 4
Dependent Claim
13 words
The compound of claim 1 wherein said pharmaceutically acceptable salts are sodium salts.
Claim 5
Dependent Claim
1 words
8,10-dideazaminopterin.
Claim 6
Dependent Claim
1 words
8,10-dideazaminopterin.
Claim 7
Dependent Claim
1 words
10-Methyl-8,10-dideazaminopterin.
Claim 8
Dependent Claim
1 words
10-Methyl-8,10-dideazaminopterin.
Claim 9
Dependent Claim
1 words
10-Propyl-8,10-dideazaminopterin.
Claim 10
Dependent Claim
1 words
10-Propyl-8,10-dideazaminopterin.
Claim 11
Dependent Claim
1 words
10-Amyl-8,10-dideazaminopterin.
Claim 12
Dependent Claim
1 words
10-Amyl-8,10-dideazaminopterin.
Claim 13
Dependent Claim
27 words
An antineoplastic composition comprising a therapeutically effective amount of the compound of claim 1, 2, 3, 4, 5, 6, or 7 combined with a pharmaceutically acceptable carrier.
Claim 14
Dependent Claim
34 words
An antineoplastic composition for parenteral administration comprising a therapeutically effective amount of a sodium salt of the compound of claim 1, 2, 4, 5, 6, or 7 dissolved in a pharmaceutically acceptable aqueous solvent.
Claim 15
Dependent Claim
32 words
A method of inhibiting neoplastic growth in a living animal comprising administering a therapeutically effective amount of the compound of claim 1, 2, 3, 4, 5, 6, or 7 to the animal.
Claim 16
Dependent Claim
42 words
A method of inhibiting neoplastic growth in a living animal comprising administering a therapeutically effective amount of an aqueous solution of a sodium salt of the compound of claim 1, 2, 4, 5, 6, or 7 to the animal intravenously or subcutaneously.
References Cited (Backward Citations)
GB1534238A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-17 | 1988-01-16 | 1988-07-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-17 | 1992-01-16 | 1992-07-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-17 | 1996-01-16 | 1996-07-17 | $7700.00 | Window Closed / Lapsed |