US4457942A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for waste nitrogen removal
Assignee: Ucyclyd Pharma Inc
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Filing: 1982-08-20
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Granted: 1984-07-03
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Expires: 2002-08-20
Abstract
Abstract A method of alleviating the accumulation of waste nitrogen in human beings is disclosed, wherein phenylbutyrate, or even numbered conger thereof, is administered to a patient having such waste nitrogen accumulation. The phenylbutyrate or other compound is broken down by beta-oxidation to eventually yield phenylacetate, which is known to be useful for removing waste nitrogen from the blood stream. The present invention provides a solution to the offensive odor of phenylacetate, which is unpalatable to patients, and also can eliminate peaks and valleys of drug levels in the patient, due to the gradual formation of the desired compound phenylacetate in the patient's body.
Inventors
- 👤 Saul W. Brusilow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
108 words
A process for controlling waste nitrogen accumulation disease in a patient suffering from such waste nitrogen accumulation disease caused by an impairment in the normal synthesis of urea from ordinary waste nitrogen in the body or in the normal excretion thereof, said process comprising administering to the patient an effective amount of at least one compound of the formula: ##STR3## wherein n is 2, 4, 6 or 8, or a pharmaceutically, acceptable salt thereof, and wherein the amount of said compound administered to the patient is sufficient to produce enough phenylacetate to react with waste nitrogen to form an amino acylation product for urinary discharge of said product.
Claim 2
Dependent Claim
108 words
A process for controlling waste nitrogen accumulation disease in a patient suffering from such waste nitrogen accumulation disease caused by an impairment in the normal synthesis of urea from ordinary waste nitrogen in the body or in the normal excretion thereof, said process comprising administering to the patient an effective amount of at least one compound of the formula: ##STR3## wherein n is 2, 4, 6 or 8, or a pharmaceutically, acceptable salt thereof, and wherein the amount of said compound administered to the patient is sufficient to produce enough phenylacetate to react with waste nitrogen to form an amino acylation product for urinary discharge of said product.
Claim 3
Dependent Claim
20 words
The process of claim 1 wherein the administration is continued until the accumulated waste nitrogen is discharged as urinary nitrogen.
Claim 4
Dependent Claim
15 words
The process of claim 1 wherein the patient is one with a urea cycle enzymopathy.
Claim 5
Dependent Claim
14 words
The process of claim 1 wherein the patient is one suffering from renal failure.
Claim 6
Dependent Claim
15 words
The process of claim 1 wherein the patient is one suffering from a hepatic failure.
Claim 7
Dependent Claim
14 words
The process of claim 1 wherein said compound is phenylbutyrate, or a salt thereof.
Claim 8
Dependent Claim
12 words
The process of claim 1 wherein the salt is the calcium salt.
Claim 9
Dependent Claim
12 words
The process of claim 1 wherein the salt is the sodium salt.
Claim 10
Dependent Claim
11 words
The process of claim 1 wherein the compound is orally administered.
Claim 11
Dependent Claim
11 words
The process of claim 1 wherein the compound is administered intravenously.
References Cited (Backward Citations)
US4284647A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-03 | 1988-01-02 | 1988-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-03 | 1992-01-02 | 1992-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-03 | 1996-01-02 | 1996-07-03 | $7700.00 | Window Closed / Lapsed |