US4284647A
Expired / Lapsed
US
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Process for waste nitrogen removal
Assignee: Johns Hopkins University
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Filing: 1980-03-31
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Granted: 1981-08-18
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Expires: 2000-03-31
Abstract
Abstract A process for controlling waste nitrogen accumulation diseases in humans which comprises administering an effective amount of at least one compound selected from the group consisting of benzoic acid, phenylacetic acid and the non-toxic, pharmaceutically-acceptable salts of the acids to a human suffering from waste nitrogen accumulation.
Inventors
- 👤 Saul W. Brusilow
- 👤 Mark L. Batshaw
- 👤 Norman S. Radin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:38
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
100 words
A process for controlling waste nitrogen accumulation diseases in humans, caused by an impairment in the normal synthesis of urea from ordinary waste nitrogen in the body or in the normal excretion thereof, said process comprising administering an effective amount of at least one compound selected from the group consisting of benzoic acid, phenylacetic acid and the non-toxic, pharmaceutically-acceptable salts of said acids to a human suffering from such waste nitrogen accumulation disease, the amount of said compound used being sufficient to react with the waste nitrogen to form an amino acid acylation product for urinary discharge of said product.
Claim 2
Dependent Claim
100 words
A process for controlling waste nitrogen accumulation diseases in humans, caused by an impairment in the normal synthesis of urea from ordinary waste nitrogen in the body or in the normal excretion thereof, said process comprising administering an effective amount of at least one compound selected from the group consisting of benzoic acid, phenylacetic acid and the non-toxic, pharmaceutically-acceptable salts of said acids to a human suffering from such waste nitrogen accumulation disease, the amount of said compound used being sufficient to react with the waste nitrogen to form an amino acid acylation product for urinary discharge of said product.
Claim 3
Dependent Claim
19 words
The process of claim 1 wherein a mixture of benzoic acid and phenylacetic acid, or salts thereof, is administered.
Claim 4
Dependent Claim
20 words
The process of claim 1 wherein the administration is continued until the accumulated waste nitrogen is discharged as urinary nitrogen.
Claim 5
Dependent Claim
14 words
The process of claim 1 wherein the human is one with a urea-cycle enzymopathy.
Claim 6
Dependent Claim
13 words
The process of claim 1 wherein the human is one suffering from uremia.
Claim 7
Dependent Claim
15 words
The process of claim 1 wherein the human is one suffering from a hepatic disorder.
Claim 8
Dependent Claim
14 words
The process of claim 1 wherein the human is one suffering from Reye's syndrome.
Claim 9
Dependent Claim
33 words
The process of claim 1 wherein the administration of the benzoic acid or phenylacetic acid, or salts thereof, synthesizes hippuric acid and phenylacetylglutamine, respectively, and the synthesized product is discharged as urinary nitrogen.
Claim 10
Dependent Claim
11 words
The process of claim 1 wherein the salt is sodium salt.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-17 | 1985-02-16 | 1985-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-17 | 1989-02-16 | 1989-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-17 | 1993-02-16 | 1993-08-18 | $7700.00 | Window Closed / Lapsed |