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US4457939A
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US
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Aldose reductase inhibiting 5-(2-alkoxy-3-substituted phenyl)hydantoins
Assignee: Pfizer Inc
•
Filing: 1982-11-01
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Granted: 1984-07-03
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Expires: 2002-11-01
Abstract
Abstract A series of 5-(2-alkoxy-3-substituted phenyl)hydantoins and pharmaceutically acceptable salts thereof useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications; intermediates therefore; and processes for preparation of said compounds.
Inventors
- 👤 Rodney C. Schnur
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:32
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/66; C07D233/72; C07D407/00; C07D407/02; C07D407/12; C07D233/76; C07D233/78
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
58 words
A method for treating a diabetic host for diabetes-associated complications which comprises administering to said host an effective amount of a compound having the formula ##STR7## or a pharmaceutically acceptable salt thereof, wherein each of X is fluoro, chloro, (C 1-4 )alkyl or nitro; Y is fluoro, chloro or (C 1-4 )alkyl; and Z is (C 1-4 )alkoxy.
Claim 2
Independent Claim
58 words
A method for treating a diabetic host for diabetes-associated complications which comprises administering to said host an effective amount of a compound having the formula ##STR7## or a pharmaceutically acceptable salt thereof, wherein each of X is fluoro, chloro, (C 1-4 )alkyl or nitro; Y is fluoro, chloro or (C 1-4 )alkyl; and Z is (C 1-4 )alkoxy.
Claim 3
Dependent Claim
12 words
A method according to claim 1, wherein X is fluoro or chloro.
Claim 4
Dependent Claim
12 words
A method according to claim 2, wherein Y is chloro or methyl.
Claim 5
Dependent Claim
12 words
A method according to claim 3, wherein Z is methoxy or ethoxy.
Claim 6
Dependent Claim
17 words
The method according to claim 4, wherein X is chloro, Y is methyl and Z is methoxy.
Claim 7
Dependent Claim
17 words
The method according to claim 4, wherein X is chloro, Y is methyl and Z is ethoxy.
Claim 8
Dependent Claim
17 words
The method according to claim 4, wherein X is fluoro, Y is chloro and Z is ethoxy.
Claim 9
Dependent Claim
17 words
The method according to claim 4 wherein X is fluoro, Y is chloro and Z is methoxy.
References Cited (Backward Citations)
GB2012756A
Cited
GB2053206A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-03 | 1988-01-02 | 1988-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-03 | 1992-01-02 | 1992-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-03 | 1996-01-02 | 1996-07-03 | $7700.00 | Window Closed / Lapsed |