Patent US4456748A successfully refreshed from Google Patents.
US4456748A
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Hybrid human leukocyte interferons
Assignee: Hoffmann La Roche Inc
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Filing: 1981-09-25
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Granted: 1984-06-26
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Expires: 2001-09-25
Abstract
Abstract Disclosed herein are methods and means of microbially preparing novel human hybrid leukocyte interferons, useful in the treatment of viral and neoplastic diseases, by DNA recombination of parental interferon genes, taking advantage of common restriction endonuclease cleavage sites therein and in carrier expression plasmids.
Inventors
- 👤 David V. Goeddel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 11:05
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/555; C07K14/56; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/70; C12N15/71; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/142
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
62 words
Double stranded DNA comprising a strand encoding a polypeptide of approximately 165-166 amino acids, the amino acid sequence of said polypeptide comprising, in sequence, discrete sub-sequences corresponding in amino acid identity and number to sub-sequences of different, naturally, occurring leukocyte interferons, the amino acid sequence of said polypeptide differing in overall sequence from the amino acid sequence of naturally occurring leukocyte interferons.
Claim 2
Dependent Claim
62 words
Double stranded DNA comprising a strand encoding a polypeptide of approximately 165-166 amino acids, the amino acid sequence of said polypeptide comprising, in sequence, discrete sub-sequences corresponding in amino acid identity and number to sub-sequences of different, naturally, occurring leukocyte interferons, the amino acid sequence of said polypeptide differing in overall sequence from the amino acid sequence of naturally occurring leukocyte interferons.
Claim 3
Dependent Claim
50 words
The double stranded DNA of claim 1 wherein the encoded polypeptide constitutes a conjugate of substantial amino acid sequences drawn from two or more different leukocyte interferons selected from the group consisting of LeIF A, LeIF B, LeIF C, LeIF D, LeIF E, LeIF F, LeIF G, and LeIF H.
Claim 4
Dependent Claim
37 words
The double stranded DNA of claim 2 wherein said encoded polypeptide is selected from the group consisting of LEIF-A/D, LEIF-D/A, LEIF-A/B, LEIF-A/F, LEIF-A/G, LEIF-A/I, LEIF-B/A, LEIF-B/D, LEIF-B/F, LEIF-B/G, LEIF-D/B, LEIF-D/F, LEIF-D/G, LEIF-F/A, LEIF-F/B, LEIF-F/D, LEIF-F/G, and LEIF-I/A.
Claim 5
Dependent Claim
18 words
The double stranded DNA of claim 3 which encodes a polypeptide of the sequence LeIF AD (Pvu II).
Claim 6
Dependent Claim
19 words
The double stranded DNA of claim 3 wherein said encoded polypeptide is of the sequence LeIF AD (Bgl II).
References Cited (Backward Citations)
US4262090A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-26 | 1987-12-26 | 1988-06-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-26 | 1991-12-26 | 1992-06-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-26 | 1995-12-26 | 1996-06-26 | $7700.00 | Window Closed / Lapsed |