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US4455301A
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Antihemophilic factor concentrate
Assignee: Bayer Corp
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Filing: 1982-09-29
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Granted: 1984-06-19
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Expires: 2002-09-29
Abstract
Abstract Novel antihemophilic factor concentrates and process for making the same are disclosed. An aqueous solution of anithemophilic factor proteins is obtained, preferably by solubilizing antihemophilic factor proteins from blood plasma cryoprecipitate in water. The aqueous solution is purified to remove unwanted protein, for example, by mixing the aqueous solution with aluminum hydroxide. Then, the aqueous solution is ultrafiltered to concentrate it, mixed with buffer and saline and adjusted to an acid pH, and freeze-dried.
Inventors
- 👤 Gautam Mitra
- 👤 John L. Lundblad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 20:55
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
45 words
Antihemophilic factor concentrate containing Von Willebrandt factor (VIIIR:WF), procoagulant factor (VIII:C) and fibrinogen (φ) wherein the VIII:C/VIIIR:WF ratio is in the range of about 1/0.5-1 and wherein the ratio of procoagulant factor to milligrams of fibrinogen (VIII:C/mg φ) is in the range of about 2.6-4.0/1.
Claim 2
Dependent Claim
45 words
Antihemophilic factor concentrate containing Von Willebrandt factor (VIIIR:WF), procoagulant factor (VIII:C) and fibrinogen (φ) wherein the VIII:C/VIIIR:WF ratio is in the range of about 1/0.5-1 and wherein the ratio of procoagulant factor to milligrams of fibrinogen (VIII:C/mg φ) is in the range of about 2.6-4.0/1.
Claim 3
Dependent Claim
20 words
The product of claim 1 wherein the concentration of Von Willebrandt factor is about 15 units per milliliter or more.
Claim 4
Dependent Claim
18 words
The product of claim 1 wherein the ratio of Von Willebrandt factor to procoagulant factor is about 1/1.
References Cited (Backward Citations)
US4289691A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-19 | 1987-12-19 | 1988-06-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-19 | 1991-12-19 | 1992-06-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-19 | 1995-12-19 | 1996-06-19 | $7700.00 | Window Closed / Lapsed |