Device for column chromatography apparatus

Claim 2

In a fluid chromatography apparatus, a device for operably connecting a precolumn and a column, said device comprising a body member including support surfaces for a column inlet and a precolumn outlet and including a central aperture, first conduit means respectively extending from said aperture to said precolumn outlet and column inlet, and second conduit means extending from said aperture to a plurality of external fluid inlet and/or outlet means, and a stopper for said central aperture, said stopper comprising a passage for directly interconnecting said precolumn outlet with said column inlet by means of a substantially linear flow path, and passages for independently connecting each of said precolumn outlet and column inlet to individual ones of said external fluid inlet and/or outlet conduits.

Claim 3

The device as defined by claim 1, said stopper being essentially cylindrical and adapted for rotation within said central aperture, and said various connections adapted to be made by rotation of said stopper.

Claim 4

The device as defined by claim 2, said first conduit means comprising an essentially diametrical linear conduit, said stopper including orifice means for directing external fluid inlet and/or outlet to or from said precolumn outlet and column inlet.

Claim 5

The device as defined by claim 3, said conduit and orifice means being located in essentially the same plane, perpendicular to said stopper.

Claim 6

The device as defined by claim 1, said stopper being of piston type, and said various connections adapted to be made by translation and rotation of said stopper.

Claim 7

The device as defined by claim 5, said connecting means comprising said stopper comprising a plurality of essentially diametrical conduits offset both angularly and longitudinally with respect to the axis of said stopper, and respective grooves therefor, along the generatrices of said stopper.

Claim 8

The device as defined by claim 5, the connecting means borne by said stopper comprising a pair of V-shaped conduits located in a first plane perpendicular to the axis thereof, the angle of the V being greater than 90°, said conduits extending to four orifices opening onto the external surface of said stopper, said orifices being angularly offset at angles of about 90°, said stopper including an internal cavity communicating to the exterior thereof by two passageways situated in the same plane containing the axis of the stopper and extending to two orifices opening onto the external surface of said stopper, said two orifices and one of the orifices comprising said V-shaped conduit being located on the same generatrix of the stopper, and a tubular, essentially diametrical conduit extending through said internal cavity located in a second plane perpendicular to the axis of the stopper and containing one of the passageways connecting said cavity to the exterior of the stopper, said tubular conduit being perpendicular to the plane containing said passageways.

Claim 10

The device as defined by claim 8, wherein said body member and said control means further comprise means for visually displaying the connections established.

Claim 11

The device as defined by claim 1, said body member including means for securing the column thereto, with the column inlet being applied against a support surface thereof.

Claim 12

The device as defined by claim 10, comprising means for securing the precolumn thereto, with the precolumn outlet being applied against a support surface thereof.

Claim 13

The device as defined by claim 11, said means for securing the column and precolumn to the body member each comprising a cylindrical threaded zone.

Claim 14

The device as defined by claim 1, further comprising means for the injection therein of at least one standard.

Claim 15

The device as defined by claim 13, said injection means comprising a piston-type valve.

Claim 16

The device as defined by claim 1, wherein said body member comprises an integral assemblage of block elements.

Claim 17

The device as defined by claim 15, comprising, in the direction of flow of sample, a first block element comprising a support surface for the precolumn outlet thereto and a conduit in communicating relationship with said precolumn outlet, a second block element comprising means for interconnecting the column inlet with the precolumn outlet, and individually independently with fluid inlet and/or outlet means, either internally or externally, and a third block element comprising a support surface for the column inlet thereto and a conduit in communicating relationship with said column inlet.

Claim 18

The device as defined by claim 16 in which the first block element and the third block element comprise means for securing respectively a precolumn and a column.

Claim 19

The device as defined by claim 16, further comprising a fourth block element, located between said second and said third block elements, and said fourth block element comprising means for the injection of at least one standard.

Claim 20

The device as defined by claim 18, said gasket means being fabricated from polytetrafluoroethylene.

Claim 21

The device as defined by claim 16, comprising gasket means disposed between each two adjacent block elements.