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US4454289A
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Polysaccharides having anticarcinogenic activity and method for producing same
Assignee: Takara Shuzo Co Ltd
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Filing: 1982-02-23
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Granted: 1984-06-12
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Expires: 2002-02-23
Abstract
Abstract The invention relates to a high molecular weight β-1,3-glucan composed of repeated glucopyranose units, each unit being represented by the formula: ##STR1## The β-1,3-glucan exhibits anticarcinogenic activity. A process for producing said glucan is also claimed.
Inventors
- 👤 Kazuo Nakajima
- 👤 Yoshiaki Hirata
- 👤 Hiroyuki Uchida
- 👤 Tomoko Shiomi
- 👤 Tsutomu Taniguchi
- 👤 Akira Obayashi
- 👤 Osamu Tanabe
- 👤 Takuma Sasaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 21:59
CPC Classifications
C; C12; C12P; C12P19/00; A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; C07; C07H; C07H3/00; C07H3/06; C12P19/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
108 words
A β-1,3-glucan composed of repeated glucopyranose units, each unit being represented by the formula: ##STR8## having an intrinsic viscosity (η)=20-25, a molecular weight of more than 2.5×10 5 by the gel filtration method and an anticarcinogenic activity against Sarcoma-180, Ehrlich carcinoma, Ehrlich ascites tumor and Meth-A (fibrosarcoma), said β-1,3-glucan being produced by a process which consists essentially of forming a filtered broth from a culture medium or liquid extract of fruitbodies or mycelium of a strain which is capable of producing the β-1,3-glucan and belongs to the genus Pseudoplectania of the class Discomycetes, and recovering the β-1,3-glucan from the filtered broth or liquid extract in a purified form.
Claim 2
Dependent Claim
108 words
A β-1,3-glucan composed of repeated glucopyranose units, each unit being represented by the formula: ##STR8## having an intrinsic viscosity (η)=20-25, a molecular weight of more than 2.5×10 5 by the gel filtration method and an anticarcinogenic activity against Sarcoma-180, Ehrlich carcinoma, Ehrlich ascites tumor and Meth-A (fibrosarcoma), said β-1,3-glucan being produced by a process which consists essentially of forming a filtered broth from a culture medium or liquid extract of fruitbodies or mycelium of a strain which is capable of producing the β-1,3-glucan and belongs to the genus Pseudoplectania of the class Discomycetes, and recovering the β-1,3-glucan from the filtered broth or liquid extract in a purified form.
Claim 3
Dependent Claim
55 words
The high molecular weight β-1,3-glucan according to claim 1, wherein said β-1,3-glucan is as isolated from an extract of mycelium and/or fruitbodies of a strain which is capable of producing an anticarcinogenic β-1,3-glucan and which belongs to the genus Pseudoplectania of class Discomycetes or from a culture medium in which said strain has been incubated.
Claim 4
Dependent Claim
22 words
The high molecular weight β-1,3-glucan according to claim 2, wherein said strain is Pseudoplectania nigrella (Pers.) Fuckel K-1426 (FERM-P 5803, ATCC 20609).
Claim 5
Dependent Claim
108 words
A process for producing a high molecular weight β-1,3-glucan composed of repeated glucopyranose units, each unit being represented by the formula: ##STR9## having an intrinsic viscosity (η)=20-25, a molecular weight of more than 2.5×10 5 by the gel filtration method and an anticarcinogenic activity against Sarcoma-180, Ehrlich carcinoma, Ehrlich ascites tumor and Meth-A fibrosarcoma, which consists essentially of forming a filtered broth from a culture medium or liquid extract of fruitbodies or mycelium or a strain which is capable of producing the β-1,3-glucan and belongs to the genus Pseudoplectania of the class Discomycetes, and recoverying the β-1,3-glucan from the filtered broth or liquid extract in a purified form.
Claim 6
Dependent Claim
108 words
A process for producing a high molecular weight β-1,3-glucan composed of repeated glucopyranose units, each unit being represented by the formula: ##STR9## having an intrinsic viscosity (η)=20-25, a molecular weight of more than 2.5×10 5 by the gel filtration method and an anticarcinogenic activity against Sarcoma-180, Ehrlich carcinoma, Ehrlich ascites tumor and Meth-A fibrosarcoma, which consists essentially of forming a filtered broth from a culture medium or liquid extract of fruitbodies or mycelium or a strain which is capable of producing the β-1,3-glucan and belongs to the genus Pseudoplectania of the class Discomycetes, and recoverying the β-1,3-glucan from the filtered broth or liquid extract in a purified form.
Claim 7
Dependent Claim
19 words
The process according to claim 4, wherein the strain is Pseudoplectania nigrella (Pers.) Fuckel K-1426 (FERM-P 5803, ATCC 20609).
References Cited (Backward Citations)
US4225673A
Cited
US4237266A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |