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Patent US4454125A successfully refreshed from Google Patents.
US4454125A
Expired / Lapsed
US
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Dry powder formulations having improved flow and compressibility characteristics, and method for the preparation thereof
Assignee: Individual
•
Filing: 1982-04-22
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Granted: 1984-06-12
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Expires: 2002-04-22
Abstract
Abstract Dry, stable, self-lubricating formulations for use as pharmaceuticals or vitamin/mineral supplements, which do not require the inclusion of fillers, lubricants, binders and other conventional excipients, and which exhibit excellent free flowability and compressibility characteristics, are produced by incorporating crystalline ascorbic acid or physiologically acceptable ascorbate salts therein.
Inventors
- 👤 Harry B. Demopoulos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 17:03
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7135; A61K31/714; A61K31/33; A61K31/335; A61K31/365; A61K31/375; A61K47/00; A61K47/06; A61K47/22; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
49 words
In a dry powder, multi-vitamin encapsulation formulation, the improvement comprising the use of a lubricant consisting essentially of crystalline ascorbic acid or a crystalline physiologically acceptable ascorbate salt having particle sizes passing from 200 to 10 mesh screens, in an amount of from 5-90% by weight of said formulation.
Claim 2
Dependent Claim
49 words
In a dry powder, multi-vitamin encapsulation formulation, the improvement comprising the use of a lubricant consisting essentially of crystalline ascorbic acid or a crystalline physiologically acceptable ascorbate salt having particle sizes passing from 200 to 10 mesh screens, in an amount of from 5-90% by weight of said formulation.
Claim 3
Independent Claim
51 words
A method for improving the flow and compressibility characteristics of a dry powder, multi-vitamin encapsulation formulation, which comprises adding as the lubricant crystalline ascorbic acid or a crystalline physiologically acceptable ascorbate salt, having particle sizes passing from 200 to 10 mesh screens, in an amount of from 5-90% by weight thereof.
Claim 4
Independent Claim
51 words
A method for improving the flow and compressibility characteristics of a dry powder, multi-vitamin encapsulation formulation, which comprises adding as the lubricant crystalline ascorbic acid or a crystalline physiologically acceptable ascorbate salt, having particle sizes passing from 200 to 10 mesh screens, in an amount of from 5-90% by weight thereof.
Claim 5
Dependent Claim
60 words
The method of claim 2, wherein the formulation is prepared by blending cyanocobalamin crystals having surface areas of from 0.02 to 0.2 mm 2 with ascorbic acid or physiologically acceptable ascorbate salt crystals having an average particle size passing from 200 to 10 mesh, and adsorbing one or more other B vitamins on the ascorbic acid or ascorbate salt crystals.
Claim 6
Dependent Claim
32 words
The dry powder formulation of claim 1, comprising a multi-vitamin composition consisting essentially of one or more B vitamins in admixture with said crystalline ascorbic acid or crystalline physiologically acceptable ascorbate salt.
Claim 7
Dependent Claim
50 words
The dry powder formulation of claim 3, wherein said multi-vitamins consist essentially of cyanocobalamin crystals having lengths of from 0.01 to 1 mm, and widths of from 0.01 to 0.2 mm and, adsorbed on said crystalline ascorbic acid or crystalline physiologically acceptable ascorbate salt, one or more other B vitamins.
Claim 8
Dependent Claim
68 words
The dry powder formulation of claim 4, consisting essentially of the following ingredients in the proportions indicated: ______________________________________
Parts by Weight
______________________________________
Ascorbic acid From 400 to 1600 parts
Calcium pantothenate
From 30 to 120 parts
Thiamine hydrochloride
From 20 to 80 parts
Pyridoxine From 20 to 80 parts
Niacin From 10 to 40 parts
Riboflavin From 2 to 8 parts
Cyanocobalamin From 0.1 to 0.4 parts
______________________________________
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |