Patent US4454107A successfully refreshed from Google Patents.
US4454107A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tc99m-Phenida, radioscintigraphic agent for diagnosis of hepatoniliary disease
Assignee: Merck Frosst Canada and Co
•
Filing: 1982-08-30
•
Granted: 1984-06-12
•
Expires: 2002-08-30
Abstract
Abstract This invention relates to novel derivatives of imino diacetic acid of the formula: <IMAGE> wherein R1 is selected from the group consisting of: <IMAGE> <IMAGE> +TR <IMAGE> wherein X is halo (chloro, bromo or iodo) and R2 is lower alkyl of from 1-5 carbon atoms. It also relates to a novel diagnostic kit for hepatobiliary imaging comprising ingredients employed in the intravenous injection of a complex of technetium 99m, and an imino diacetic acid of the above formula. It also relates to a process for preparing said compounds by reaction of nitrilotriacetic acid anhydride and an amine of the formula R1NH2 wherein R1 is as defined hereinabove.
Inventors
- 👤 Richard E. Rolleston
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 14:47
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0404; A61K51/0406; A61K51/0474; A61K51/0478; C; C07; C07D; C07D265/00; C07D265/28; C07D265/30; C07D265/32; C07D277/00; C07D277/60; C07D277/62; C07D277/68; C07D277/82; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
33 words
An imino-diacetic acid compound of the formula: ##STR9## wherein R 1 is selected from the group consisting of: ##STR10## wherein X is halo and R 2 is loweralkyl of from 1-5 carbon atoms.
Claim 2
Dependent Claim
33 words
An imino-diacetic acid compound of the formula: ##STR9## wherein R 1 is selected from the group consisting of: ##STR10## wherein X is halo and R 2 is loweralkyl of from 1-5 carbon atoms.
Claim 3
Dependent Claim
9 words
A compound of claim 1 which is N-[N'-(4-chlorobenzothiazol-2-yl)carbamoylmethyl]iminodiacetic acid.
Claim 4
Dependent Claim
9 words
A compound of claim 1 which is N-[N'-(6-ethoxybenzothiazol-2-yl)carbamoylmethyl]iminodiacetic acid.
Claim 5
Dependent Claim
9 words
A compound of claim 1 which is N-[N'-{4-(6-methylbenzothiazol-2-yl)phenyl}carbamoylmethyl]iminodiacetic acid.
Claim 6
Dependent Claim
9 words
A compound of claim 1 which is N-[N'-{2-(2-chlorobenzoyl-4-chlorophenyl}carbamoylmethyl]iminodiacetic acid.
Claim 7
Dependent Claim
14 words
A compound according to claim 1 of the formula ##STR11## wherein X is halogen.
Claim 8
Dependent Claim
10 words
A compound according to claim 6 of the formula ##STR12##
Claim 9
Dependent Claim
20 words
A molecular complex comprising a mixture of technetium 99m, a compound of claim 1 and a water soluble stannous salt.
Claim 10
Dependent Claim
33 words
A diagnostic kit for the preparation of an injectable solution incorporating technetium 99m which comprises a container of a lyophilized mixture of a compound of claim 1 and a water soluble tin salt.
Claim 11
Dependent Claim
30 words
A diagnostic kit for the preparation of an injectable solution incorporating technetium 99m which comprises a container of a freeze-dried mixture of the compound of claim 1 and stannous chloride.
Claim 12
Dependent Claim
33 words
A diagnostic kit according to claim 9 in which the weight ratio of the components is from 10-100 parts by weight of N-[N'-(2-benzoyl-4-chlorophenyl)carbamoylmethyl]iminodiacetic acid and 1 part of tin as stannous chloride dihydrate.
Claim 13
Dependent Claim
23 words
A method for imaging the hepatobiliary system which comprises the intravenous administration of a sterile solution of a molecular complex of claim 8.
References Cited (Backward Citations)
GB1308793A
Cited
US4017596A
Cited
GB1545427A
Cited
US4316883A
Cited
US4318898A
Cited
US4350674A
Cited
GB2090252A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |