Patent US4452682A successfully refreshed from Google Patents.
US4452682A
Expired / Lapsed
US
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Apparatus for measuring clinical emergency check items of blood
Assignee: Hitachi Ltd
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Filing: 1980-10-24
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Granted: 1984-06-05
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Expires: 2000-10-24
Abstract
Abstract An apparatus for electrochemically measuring clinical emergency check items of blood for a short time by flowthrough system, using a small amount of whole blood as a blood sample, which comprises a blood pH/gas component sensor unit, an electrolyte component sensor unit, and/or a biochemical component sensor unit, arranged in series in this order, a sampler and these sensor units being communicated with one another through a blood sample flow passage or channel, each of the sensor units being provided with sensor electrodes and at least one reference electrode as electrochemical sensor means. Detected values from each of the sensor units are transmitted to a computer or calculator through a current amplifier and/or a differential amplifier for a differential voltage from the voltage of the reference electrode to compute pH, pressure, or concentrations from the detected values, and numerically displayed on a display device connected to the computer.
Inventors
- 👤 Yoshinori Takata
- 👤 Hiroyuki Miyagi
- 👤 Kunio Hirota
- 👤 Yasuhisa Shibata
- 👤 Kazuo Nidaira
- 👤 Fusao Shirato
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:06
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/4915; G01N33/492
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
128 words
An apparatus for measuring blood emergency check items by electrochemically measuring pH, gas component concentrations or pressures, and electrolyte component concentrations of whole blood by a flowthrough system, which comprises: (1) a sampler, (2) a blood pH/gas component sensor unit comprising a flow cell provided with a pH sensor electrode, at least one gas sensing electrode and a reference electrode. (3) a blood electrolyte component sensor unit comprising a flow cell provided with a plurality of ion sensing electrodes and a reference electrode, the sampler and the sensor units being arranged separately from each other and in series in the order given, and (4) a blood sample flow passage providing successive communication between the sampler, the blood pH/gas component sensor unit, and the blood electrolyte component sensor unit.
Claim 2
Independent Claim
128 words
An apparatus for measuring blood emergency check items by electrochemically measuring pH, gas component concentrations or pressures, and electrolyte component concentrations of whole blood by a flowthrough system, which comprises: (1) a sampler, (2) a blood pH/gas component sensor unit comprising a flow cell provided with a pH sensor electrode, at least one gas sensing electrode and a reference electrode. (3) a blood electrolyte component sensor unit comprising a flow cell provided with a plurality of ion sensing electrodes and a reference electrode, the sampler and the sensor units being arranged separately from each other and in series in the order given, and (4) a blood sample flow passage providing successive communication between the sampler, the blood pH/gas component sensor unit, and the blood electrolyte component sensor unit.
Claim 3
Independent Claim
124 words
An apparatus for measuring blood emergency check items by electrochemically measuring pH, gas component concentrations or pressures, and biochemical component concentrations of whole blood by a flowthrough system, which comprises: (1) a sampler, (2) a blood pH/gas component sensor unit comprising a flow cell provided with a pH sensor electrode, at least one gas sensing electrode and a reference electrode. (3) a blood biochemical component sensor unit comprising a flow cell provided with immobilized enzyme and a reference electrode, the sampler and the sensor units being arranged separately from each other and in series in the order given, and (4) a blood sample flow passage providing successive communication between the sampler, the blood pH/gas component sensor unit, and the blood biochemical component sensor unit.
Claim 4
Independent Claim
124 words
An apparatus for measuring blood emergency check items by electrochemically measuring pH, gas component concentrations or pressures, and biochemical component concentrations of whole blood by a flowthrough system, which comprises: (1) a sampler, (2) a blood pH/gas component sensor unit comprising a flow cell provided with a pH sensor electrode, at least one gas sensing electrode and a reference electrode. (3) a blood biochemical component sensor unit comprising a flow cell provided with immobilized enzyme and a reference electrode, the sampler and the sensor units being arranged separately from each other and in series in the order given, and (4) a blood sample flow passage providing successive communication between the sampler, the blood pH/gas component sensor unit, and the blood biochemical component sensor unit.
Claim 5
Independent Claim
156 words
An apparatus for measuring blood emergency check items by electrochemically measuring pH, gas component concentrations or pressures, electrolyte component concentrations, and biochemical component concentrations of whole blood by a flowthrough system, which comprises: (1) a sampler, (2) a blood pH/gas component sensor unit comprising a flow cell provided with a pH sensor electrode, at least one gas sensing electrode and a reference electrode, (3 ) a blood electrolyte component sensor unit comprising a flow cell provided with a plurality of ion sensing electrodes and a reference electrode, (4) a blood biochemical component sensor unit comprising a flow cell provided with immobilized enzyme and a reference electrode, the sampler and the sensor units being arranged separately from each other and in series in the order given. (5) a blood sample flow passage providing successive communication between the sampler, the blood pH/gas component sensor unit, the blood electrolyte component sensor unit, and the blood biochemical component sensor unit.
Claim 6
Independent Claim
156 words
An apparatus for measuring blood emergency check items by electrochemically measuring pH, gas component concentrations or pressures, electrolyte component concentrations, and biochemical component concentrations of whole blood by a flowthrough system, which comprises: (1) a sampler, (2) a blood pH/gas component sensor unit comprising a flow cell provided with a pH sensor electrode, at least one gas sensing electrode and a reference electrode, (3 ) a blood electrolyte component sensor unit comprising a flow cell provided with a plurality of ion sensing electrodes and a reference electrode, (4) a blood biochemical component sensor unit comprising a flow cell provided with immobilized enzyme and a reference electrode, the sampler and the sensor units being arranged separately from each other and in series in the order given. (5) a blood sample flow passage providing successive communication between the sampler, the blood pH/gas component sensor unit, the blood electrolyte component sensor unit, and the blood biochemical component sensor unit.
Claim 7
Dependent Claim
124 words
An apparatus according to claim 1, 2 or 3, wherein the blood pH/gas component sensor unit comprises a pH sensor electrode, a P O .sbsb.2 sensor electrode, or dissolved oxygen sensor electrode, a P CO .sbsb.2 sensor electrode or a bicarbonate selective sensor electrode, and a reference electrode, the sensing side of each of the electrodes is in the blood sample flow passage, while the connecting side thereof is connected to a computer through a current amplifier or a differential amplifier for a differential voltage from voltage of the reference electrode, and the computer is connected to a display device, each of resulting signals being numerically displayed on the display device as pH, oxygen concentration or pressure, bicarbonate concentration upon computation in the computer.
Claim 8
Dependent Claim
131 words
An apparatus according to claim 1 or 3, wherein the blood electrolyte component sensor unit comprises a sodium ion sensor electrode, a potassium ion sensor electrode, an ammonium ion sensor electrode and/or a calcium ion sensor electrode, a chloride ion sensor electrode, and a reference electrode, the sensing side of each of the electrodes is in the blood sample flow passage, while the connecting side thereof is connected to a computer through a differential amplifier for a differential voltage from voltage of the reference electrode, the computer is connected to a display device, each of signals being numerically displayed on the display device as a sodium ion concentration, a potassium ion concentration, an ammonium ion concentration, and/or a calcium ion concentration, or a chloride ion concentration upon computation in the computer.
Claim 9
Dependent Claim
95 words
An apparatus according to claim 2 or 3, wherein the blood biochemical component sensor unit with immobilized enzyme comprises electrodes with immobilized enzyme reactor and reference electrodes, the sensing side of each of the electrodes is in a blood sample flow passage, while the connecting side thereof is connected to a computer through a current amplifier or a differential amplifier for a differential voltage from the voltage of the reference electrode, the computer is connected to a display device, each of signals being numerically displayed as a biochemical component concentration upon computation in the computer.
Claim 10
Dependent Claim
19 words
An apparatus according to claim 1, 2 or 3, where a dialysis cell is provided between the sensor units.
Claim 11
Dependent Claim
18 words
An apparatus according to claim 1, 2 or 3, wherein sample inlets are provided between the sensor units.
Claim 12
Independent Claim
243 words
An apparatus for measuring blood emergency check items by electrochemically measuring pH, gas component concentrations or pressures, electrolyte component concentrations, and biochemical component concentrations of whole blood by a flowthrough system, which comprises: (1) a blood pH/gas component sensor unit comprising a flow cell provided with a pH sensor electrode, a P O .sbsb.2 sensor electrode and a reference electrode, the P O .sbsb.2 sensor electrode being connected to a current amplifier, and the pH sensor electrode and the reference electrode being connected to a differential amplifier, (2) a blood electrolyte component sensor unit comprising a flow cell provided with a plurality of ion sensing electrodes and a reference electrode, the plurality of the ion sensing electrodes being directed to detecting voltage potential, (3) a blood biochemical component sensor unit provided with a glucose sensor means and a urea-form nitrogen sensor means, the glucose sensor means having a reactor containing immobilized glucose oxidase and either a pair of P O .sbsb.2 sensor electrodes provided before and after the reactor containing immobilized glucose oxidase or a P H .sbsb.2 O .sbsb.2 sensor electrode provided after the reactor containing immobilized glucose oxidase, the urea-form nitrogen sensor means being provided with a reactor containing immobilized urease, a pair of ammonium ion sensor electrodes provided before and after the reactor containing immobilized urease, and a pair of reference electrodes, and (4) the sensor units being arranged separately from each other and in series in the order given.
Claim 13
Independent Claim
243 words
An apparatus for measuring blood emergency check items by electrochemically measuring pH, gas component concentrations or pressures, electrolyte component concentrations, and biochemical component concentrations of whole blood by a flowthrough system, which comprises: (1) a blood pH/gas component sensor unit comprising a flow cell provided with a pH sensor electrode, a P O .sbsb.2 sensor electrode and a reference electrode, the P O .sbsb.2 sensor electrode being connected to a current amplifier, and the pH sensor electrode and the reference electrode being connected to a differential amplifier, (2) a blood electrolyte component sensor unit comprising a flow cell provided with a plurality of ion sensing electrodes and a reference electrode, the plurality of the ion sensing electrodes being directed to detecting voltage potential, (3) a blood biochemical component sensor unit provided with a glucose sensor means and a urea-form nitrogen sensor means, the glucose sensor means having a reactor containing immobilized glucose oxidase and either a pair of P O .sbsb.2 sensor electrodes provided before and after the reactor containing immobilized glucose oxidase or a P H .sbsb.2 O .sbsb.2 sensor electrode provided after the reactor containing immobilized glucose oxidase, the urea-form nitrogen sensor means being provided with a reactor containing immobilized urease, a pair of ammonium ion sensor electrodes provided before and after the reactor containing immobilized urease, and a pair of reference electrodes, and (4) the sensor units being arranged separately from each other and in series in the order given.
Claim 14
Dependent Claim
22 words
The apparatus according to claim 9, wherein a sample inlet is provided at the upstream side of each of the sensor units.
Claim 15
Dependent Claim
32 words
The apparatus according to claim 9, wherein the reactor containing immobilized glucose oxidase is a first reactor and the reactor containing immobilized urease is a second reactor separate from said first reactor.
Claim 16
Dependent Claim
23 words
The apparatus according to claim 9, wherein the reactor containing immobilized glucose oxidase and the reactor containing immobilized urease constitute a single reactor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-05 | 1987-12-05 | 1988-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-05 | 1991-12-05 | 1992-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-05 | 1995-12-05 | 1996-06-05 | $7700.00 | Window Closed / Lapsed |