US4450153A
Expired / Lapsed
US
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Alcohol removal from blood with alcohol oxidase
Assignee: MOLDOWAN LABORATORIES Inc
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Filing: 1982-09-30
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Granted: 1984-05-22
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Expires: 2002-09-30
Abstract
Abstract The level of alcohol content (methanol or ethanol) in blood is reduced by contacting the blood alcohol with the enzyme alcohol oxidase. Injection, extracorporeal shunt (dialysis), and oral administration are contemplated as routes of administration. Suitable compositions for reducing the blood alcohol level are also provided.
Inventors
- 👤 Thomas R. Hopkins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:03
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/44; A61K38/443; A61K9/00; A61K9/0012; A61K9/0019; C; C12; C12Y; C12Y101/00; C12Y101/03; C12Y101/03013; A61K47/00; A61K47/06; A61K47/24; A61K9/0026
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
50 words
A process for reducing the alcohol content of human blood comprising contacting said alcohol with the enzyme alcohol oxidase wherein said alcohol oxidase, present in an injectable solution, is injected into the human body in the amount from about 1 to about 100 mg/Kg of body weight of the recipient.
Claim 2
Dependent Claim
50 words
A process for reducing the alcohol content of human blood comprising contacting said alcohol with the enzyme alcohol oxidase wherein said alcohol oxidase, present in an injectable solution, is injected into the human body in the amount from about 1 to about 100 mg/Kg of body weight of the recipient.
Claim 3
Dependent Claim
13 words
A process according to claim 1 wherein said alcohol is ethanol or methanol.
Claim 4
Dependent Claim
20 words
A process according to claim 1 wherein said alcohol oxidase is present in either an aqueous or isotonic saline solution.
Claim 5
Dependent Claim
16 words
A process according to claim 3 wherein said alcohol oxidase is admixed with an oxygen carrier.
Claim 6
Dependent Claim
18 words
A process according to claim 4 wherein said oxygen carrier is an aqueous emulsion of perfluorodecalin and perfluorotripropylamine.
Claim 7
Dependent Claim
15 words
A process according to claim 4 wherein said alcohol oxidase is combined with an antioxidant.
Claim 8
Dependent Claim
18 words
A process according to claim 6 wherein said antioxidant is one of ascorbic acid, ascorbyl palmitate, and monothioglycerol.
Claim 9
Dependent Claim
15 words
A process according to claim 4 wherein said alcohol oxidase is administered by intravenous injection.
Claim 10
Dependent Claim
15 words
A process according to claim 4 wherein said alcohol oxidase is administered by intramuscular injection.
Claim 11
Dependent Claim
15 words
A process according to claim 4 wherein said alcohol oxidase is administered by intraperitoneal injection.
Claim 12
Dependent Claim
14 words
A process according to claim 4 wherein niacin is present in the injection solution.
Claim 13
Dependent Claim
19 words
A process according to claim 4 wherein said alcohol oxidase is attached to either dextran or a polyethylene glycol.
Claim 14
Dependent Claim
15 words
A process according to claim 4 wherein said alcohol oxidase is in a microencapsulated form.
Claim 15
Dependent Claim
42 words
A process for reducing the alcohol content of human blood wherein said blood is contacted by renal dialysis with said alcohol oxidase, present in sterile solution, in an amount of from 1-200 mg of alcohol oxidase/Kg of body weight of the recipient.
Claim 16
Dependent Claim
42 words
A process for reducing the alcohol content of human blood wherein said blood is contacted by renal dialysis with said alcohol oxidase, present in sterile solution, in an amount of from 1-200 mg of alcohol oxidase/Kg of body weight of the recipient.
Claim 17
Dependent Claim
30 words
A process according to claim 14 wherein said blood is contacted with said alcohol oxidase for a time sufficient to reduce the level of said alcohol in the blood stream.
Claim 18
Dependent Claim
38 words
A process for reducing the alcohol content of human blood wherein alcohol oxidase is administered orally to a recipient as a pill or tablet containing an amount of alcohol oxidase from about 1 mg to about 1 gram.
Claim 19
Dependent Claim
38 words
A process for reducing the alcohol content of human blood wherein alcohol oxidase is administered orally to a recipient as a pill or tablet containing an amount of alcohol oxidase from about 1 mg to about 1 gram.
Claim 20
Dependent Claim
15 words
A process according to claim 16 wherein said alcohol oxidase is admixed with a binder.
Claim 21
Dependent Claim
22 words
A process according to claim 17 wherein said binder is one of acacia, gelatin, sucrose, methyl cellulose, alginic acid, or guar gum.
Claim 22
Dependent Claim
15 words
A process according to claim 16 wherein said alcohol oxidase is admixed with a diluent.
Claim 23
Dependent Claim
20 words
A process according to claim 19 wherein said diluent is one of lactose, starch, dibasic calcium phosphate or calcium sulfate.
Claim 24
Dependent Claim
16 words
A process according to claim 16 wherein said alcohol oxidase is admixed with a disintegrating agent.
Claim 25
Dependent Claim
23 words
A process according to claim 21 wherein said disintegrating agent is one of starch, alginic acid, microcrystalline cellulose, cross-linked providone or collodial silicates.
Claim 26
Dependent Claim
24 words
A process according to claim 16 wherein said alcohol oxidase is within an enteric coating suitable to slow down its inactivation in the stomach.
Claim 27
Dependent Claim
42 words
A process for reducing the alcohol content of human blood wherein alcohol oxidase, present in amounts from about 1-200 mg/mL of tonic, is administered to a recipient in the form of a tonic in an amount of from 1 to 50 mL.
Claim 28
Dependent Claim
42 words
A process for reducing the alcohol content of human blood wherein alcohol oxidase, present in amounts from about 1-200 mg/mL of tonic, is administered to a recipient in the form of a tonic in an amount of from 1 to 50 mL.
Claim 29
Dependent Claim
14 words
A process according to claim 24 wherein niacin is admixed with said alcohol oxidase.
Claim 30
Dependent Claim
33 words
A compositions suitable for injection into the human body which comprises the enzyme alcohol oxidase present in an injectable solution in an amount sufficient to reduce the level of alcohol in human blood.
Claim 31
Dependent Claim
33 words
A compositions suitable for injection into the human body which comprises the enzyme alcohol oxidase present in an injectable solution in an amount sufficient to reduce the level of alcohol in human blood.
Claim 32
Dependent Claim
29 words
A composition according to claim 26 suitable for injection into the human body which comprises the enzyme alcohol oxidase present in either an aqueous or a isotonic saline solution.
Claim 33
Dependent Claim
11 words
A composition according to claim 27 further comprising an oxygen carrier.
Claim 34
Dependent Claim
10 words
A composition according to claim 28 further comprising an antioxidant.
Claim 35
Dependent Claim
20 words
A composition according to claim 29 wherein said antioxidant is one of ascorbic acid, ascorbyl palmitate, monothioglycerol or sodium bisulfite.
Claim 36
Dependent Claim
18 words
A composition according to claim 28 wherein said alcohol oxidase is attached to either dextran or polyethylene glycol.
Claim 37
Dependent Claim
31 words
A composition in tablet form suitable for oral consumption which comprises the enzyme alcohol oxidase in an amount sufficient to reduce the level of alcohol in the blood and a binder.
Claim 38
Dependent Claim
31 words
A composition in tablet form suitable for oral consumption which comprises the enzyme alcohol oxidase in an amount sufficient to reduce the level of alcohol in the blood and a binder.
Claim 39
Dependent Claim
32 words
A composition according to claim 32 in the form of a tablet wherein said alcohol oxidase is present in an amount ranging from about 1 mg to about 1 g per tablet.
Claim 40
Dependent Claim
10 words
A composition according to claim 33 further comprising a diluent.
Claim 41
Dependent Claim
11 words
A composition according to claim 34 further comprising a disintegrating agent.
Claim 42
Dependent Claim
10 words
A composition according to claim 35 further comprising a lubricant.
Claim 43
Dependent Claim
22 words
A composition according to claim 36 which has an enteric coating suitable to diminish inactivation of said alcohol oxidase by the stomach.
Claim 44
Dependent Claim
41 words
A composition in the form of a tonic suitable for oral administration comprising alcohol oxidase present in an aqueous solution in an amount of about 2-200 mg per ml and sufficient to reduce the level of alcohol oxidase in human blood.
Claim 45
Dependent Claim
41 words
A composition in the form of a tonic suitable for oral administration comprising alcohol oxidase present in an aqueous solution in an amount of about 2-200 mg per ml and sufficient to reduce the level of alcohol oxidase in human blood.
Claim 46
Dependent Claim
28 words
A composition according to claim 38 wherein said alcohol oxidase is present in an amount of from about 1-200 mg of alcohol oxidase per ml of tonic solution.
References Cited (Backward Citations)
US3865726A
Cited
US3963613A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1987-05-22 | 1987-11-21 | 1988-05-22 | $2000.00 | Window Closed / Lapsed |
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