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US4447600A
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N-Acetylneuraminic acid derivatives and the preparation thereof
Assignee: Mect Corp
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Filing: 1982-05-20
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Granted: 1984-05-08
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Expires: 2002-05-20
Abstract
Abstract Nucleoside or glucose derivatives of N-acetylneuraminic acids are provided, which have immunological activity, are clinically useful, as an immuno suppressive, in particular to treat autoimmune disease such as collagenosis disease without causing any serious side-effects and may be prepared by subjecting a halide of N-acetylneuraminate derivative together with a nucleoside or a glucose to Koenigs-Knorr reaction.
Inventors
- 👤 Haruo Ogura
- 👤 Kimio Furuhata
- 👤 Toshiaki Osawa
- 👤 Satoshi Toyoshima
- 👤 Yoshiyasu Shitori
- 👤 Masayoshi Ito
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:52
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/02; C07H13/04; A; A61; A61P; A61P37/00; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/16
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
44 words
N-acetylneuraminic acid derivatives of the general formula (I): ##STR14## wherein R 1 represents hydrogen, lower alkyl or a lower alkyl substituted or non-substituted aralkyl or aryl group, R 2 is a nucleoside residue and R 3 and R 4 independently represent hydrogen or acetyl.
Claim 2
Dependent Claim
44 words
N-acetylneuraminic acid derivatives of the general formula (I): ##STR14## wherein R 1 represents hydrogen, lower alkyl or a lower alkyl substituted or non-substituted aralkyl or aryl group, R 2 is a nucleoside residue and R 3 and R 4 independently represent hydrogen or acetyl.
Claim 3
Dependent Claim
25 words
N-acetylneuraminic acid derivative as set forth in claim 1 wherein R 2 is the residue of 5-fluoro-2',3'-isopropylideneuiridine and R 3 and R 4 are acetyl.
Claim 4
Dependent Claim
29 words
N-acetylneuraminic acid derivative as set forth in claim 1 wherein R 1 is methyl, R 2 is the residue of 2',3'-di-O-acetylinosine and R 3 and R 4 are acetyl.
Claim 5
Dependent Claim
30 words
N-acetylneuraminic acid derivative as set forth in claim 1 wherein R 1 is methyl, R 2 is the residue of 2',3'-isopropylideneuridine, R 3 is hydrogen and R 4 is acetyl.
Claim 6
Dependent Claim
31 words
N-acetylneuraminic acid derivative as set forth in claim 1 wherein R 1 is methyl group, R 2 is the residue of 2',3'-isopropylideneuriidine and R 3 and R 4 are acetyl group.
References Cited (Backward Citations)
US3308117A
Cited
US4202968A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-05-08 | 1987-11-07 | 1988-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-05-08 | 1991-11-07 | 1992-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-05-08 | 1995-11-07 | 1996-05-08 | $7700.00 | Window Closed / Lapsed |