Process for the production of adenine ring system containing co-enzymes bound to macromolecules

Claim 1

A process for the production of an adenine ring system containing co-enzymes bound to a macro-molecular carrier consisting essentially of: (a) reacting a co-enzyme selected from the group consisting of AMP, ADP, ATP, NAD + and NADP, said co-enzyme having an adenine ring system substituted by an alkylene chain in the 1 position, said alkylene chain containing from 1 to 3 carbon atoms and a functional group capable of reacting with a macromolecular carrier selected from the group consisting of carboxyl, hydroxyl, --NH 2 and vinyl, with a macro-molecular carrier selected from the group consisting of dextrans, polyetherpolyols, polyethyleneimines, polyacrylamides and poly-(methylvinylether/maleic acid anhydride), said carrier having groups capable of reacting with said functional group, (b) subjecting said alkylated co-enzyme bound to said macro-molecular carrier to a Dimroth rearrangement into the N 6 -form of substitution, and (c) recovering said N 6 -substituted co-enzyme bound to said macro-molecular carrier.