US4443473A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Carbamate derivatives
Assignee: Procter and Gamble Co
•
Filing: 1982-06-03
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Granted: 1984-04-17
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Expires: 2002-06-03
Abstract
Abstract A compound, or pharmaceutically acceptable salt thereof, having the formula: <IMAGE> wherein X is O or S; wherein R is C3-C12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C3-C22 alkenyl, branched or unbranched, or benzyl; wherein R1 is H, OH or OCH3, and R2 is H or OH, at least one of R1 and R2 being OH or OCH3. These carbamates have analgesic and anti-irritant activity when administered to humans and lower animals.
Inventors
- 👤 Brian L. Buckwalter
- 👤 Thomas R. LaHann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 19:15
CPC Classifications
A; A61; A61Q; A61Q9/00; A61Q9/04; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/46; A61Q17/00; A61K2800/00; A61K2800/74; A61K2800/75
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
72 words
Compounds of formula: ##STR4## wherein X is O or S, wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C 3 -C 22 alkenyl, branched or unbranched, or benzyl, wherein R 1 is H, OH or OCH 3 and R 2 is H or OH, at least one of R 1 and R 2 being OH or OCH 3 ; and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
72 words
Compounds of formula: ##STR4## wherein X is O or S, wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C 3 -C 22 alkenyl, branched or unbranched, or benzyl, wherein R 1 is H, OH or OCH 3 and R 2 is H or OH, at least one of R 1 and R 2 being OH or OCH 3 ; and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
14 words
The sodium, potassium, calcium, magnesium, or ammonium salt of the compounds of claim 1.
Claim 4
Dependent Claim
20 words
A compound or salt according to claim 1 wherein R 1 is OCH 3 and wherein R 2 is OH.
Claim 5
Dependent Claim
12 words
A compound or salt according to claim 3 wherein X is O.
Claim 6
Dependent Claim
23 words
A compound according to claim 4 wherein R is C 6 -C 12 alkyl or aralkyl, C 6 -C 22 alkenyl, or benzyl.
Claim 7
Dependent Claim
14 words
A compound or salt according to claim 5 wherein R is benzyl or n-octyl.
Claim 8
Dependent Claim
16 words
A compound or salt according to claim 3 wherein X is S and R is n-octyl.
Claim 9
Dependent Claim
93 words
A pharmaceutical composition in unit dosage form having analgesic activity which comprises a safe and effective amount of a compound of formula: ##STR5## wherein X is O or S, wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C 3 -C 22 alkenyl, branched or unbranched, or benzyl, wherein R 1 is H, OH or OCH 3 and R 2 is H or OH, at least one of R 1 and R 2 being OH, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
93 words
A pharmaceutical composition in unit dosage form having analgesic activity which comprises a safe and effective amount of a compound of formula: ##STR5## wherein X is O or S, wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C 3 -C 22 alkenyl, branched or unbranched, or benzyl, wherein R 1 is H, OH or OCH 3 and R 2 is H or OH, at least one of R 1 and R 2 being OH, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
20 words
A composition according to claim 8 wherein the pharmaceutically acceptable salt is a sodium, potassium, calcium, magnesium, or ammonium salt.
Claim 12
Dependent Claim
18 words
A composition according to claim 8 wherein R 1 is OCH 3 and wherein R 2 is OH.
Claim 13
Dependent Claim
10 words
A composition according to claim 7 wherein X is O.
Claim 14
Dependent Claim
23 words
A composition according to claim 11 wherein R is C 6 -C 12 alkyl or aralkyl, C 6 -C 22 alkenyl or benzyl.
Claim 15
Dependent Claim
12 words
A composition according to claim 12 wherein R is benzyl or n-octyl.
Claim 16
Dependent Claim
14 words
A composition according to claim 10 wherein X is S and R is n-octyl.
Claim 17
Independent Claim
101 words
A method for providing analgesia in humans and lower animals in need thereof, which comprises the step of administering to the human or lower animal a safe and effective amount of a compound of formula: ##STR6## wherein X is O or S, wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C 3 -C 22 alkenyl, branched or unbranched, or benzyl, wherein R 1 is H, OH or OCH 3 and R 2 is H or OH, at least one of R 1 and R 2 being OH, or a pharmaceutically acceptable salt thereof.
Claim 18
Independent Claim
101 words
A method for providing analgesia in humans and lower animals in need thereof, which comprises the step of administering to the human or lower animal a safe and effective amount of a compound of formula: ##STR6## wherein X is O or S, wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C 3 -C 22 alkenyl, branched or unbranched, or benzyl, wherein R 1 is H, OH or OCH 3 and R 2 is H or OH, at least one of R 1 and R 2 being OH, or a pharmaceutically acceptable salt thereof.
Claim 19
Dependent Claim
15 words
A method according to claim 15 in which the compound or salt is administered topically.
Claim 20
Dependent Claim
15 words
A method according to claim 15 in which the compound or salt is administered parenterally.
Claim 21
Dependent Claim
15 words
A method according to claim 17 in which the compound or salt is administered intramuscularly.
Claim 22
Dependent Claim
15 words
A method according to claim 17 in which the compound or salt is administered subcutaneously.
Claim 23
Dependent Claim
18 words
A method according to claim 15 in which the compound or salt is administered in sequentially increasing doses.
Claim 24
Dependent Claim
20 words
A method according to claim 20 in which the doses are separated by a period of at least 2 hours.
Claim 25
Dependent Claim
18 words
A method according to claim 15 wherein R 1 is OCH 3 and wherein R 2 is OH.
Claim 26
Dependent Claim
10 words
A method according to claim 22 wherein X is O.
Claim 27
Dependent Claim
23 words
A method according to claim 23 wherein R is C 6 -C 12 alkyl or aralkyl, C 6 -C 22 alkenyl, or benzyl.
Claim 28
Dependent Claim
14 words
A method according to claim 22 wherein X is S and R is n-octyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-17 | 1987-10-17 | 1988-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-17 | 1991-10-17 | 1992-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-17 | 1995-10-17 | 1996-04-17 | $7700.00 | Window Closed / Lapsed |