US3983164A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenyl alkyleneoxy phenyl alkanoic acid esters
Assignee: Beecham Group PLC
•
Filing: 1974-08-05
•
Granted: 1976-09-28
•
Expires: 1994-08-05
Abstract
Abstract Pharmaceutical compositions having hypolipidaemic and/or hypoglycaemic activity, contain a substituted (4-carboxyphenoxy) phenyl alkane derivative.
Inventors
- 👤 David Edward Thorne
- 👤 Keith Howard Baggaley
- 👤 Brian Morgan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 15:54
CPC Classifications
C; C07; C07C; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07C321/00; C07C43/00; C07C43/02; C07C43/20; C07C43/205; C07C45/27; C07C45/29; C07C45/298; C07C45/45; C07C45/46; C07C47/00; C07C47/52; C07C47/575; C07C49/00; C07C49/76; C07C49/84; C07D; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/18; C07D317/24
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
228 words
A compound selected from the group consisting of a compound of the formula: ##SPC31## wherein: R 1 is carboxylic acid ester converted in the human body to a carboxylic acid group; R 2 is hydrogen, lower alkyl or lower alkoxyl; R 3 is hydrogen, halogen, lower alkyl or lower alkoxyl; R 4 is hydrogen, halogen, phenyl, lower alkyl, lower alkoxyl, halo-lower alkyl, nitro, or a carboxylic ester group; or R 3 and R 4 together form the residue of a benzene ring; q is zero or an integer from 1 to 12; and s is an integer from 2 to 6; and a compound of the formula: ##SPC32## wherein: R 1 is a carboxylic acid ester converted in the human body to a carboxylic acid group; R 2 is hydrogen, lower alkyl or lower alkoxyl; R 3 is hydrogen, halogen, lower alkyl or lower alkoxyl; and R 4 is halogen, phenyl, lower alkyl, lower alkoxy, halo-lower alkyl, nitro or a carboxylic ester group; or R 3 is halogen, lower alkyl or lower alkoxyl; and R 4 is hydrogen, halogen, phenyl, lower alkyl, lower alkoxyl, halo-lower alkyl, nitro or a carboxylic ester group; or R 3 and R 4 together form the residue of a benzene ring; q is zero or an integer from 1 to 12; x is an integer from 1 to 6; and Y is oxygen.
Claim 2
Dependent Claim
228 words
A compound selected from the group consisting of a compound of the formula: ##SPC31## wherein: R 1 is carboxylic acid ester converted in the human body to a carboxylic acid group; R 2 is hydrogen, lower alkyl or lower alkoxyl; R 3 is hydrogen, halogen, lower alkyl or lower alkoxyl; R 4 is hydrogen, halogen, phenyl, lower alkyl, lower alkoxyl, halo-lower alkyl, nitro, or a carboxylic ester group; or R 3 and R 4 together form the residue of a benzene ring; q is zero or an integer from 1 to 12; and s is an integer from 2 to 6; and a compound of the formula: ##SPC32## wherein: R 1 is a carboxylic acid ester converted in the human body to a carboxylic acid group; R 2 is hydrogen, lower alkyl or lower alkoxyl; R 3 is hydrogen, halogen, lower alkyl or lower alkoxyl; and R 4 is halogen, phenyl, lower alkyl, lower alkoxy, halo-lower alkyl, nitro or a carboxylic ester group; or R 3 is halogen, lower alkyl or lower alkoxyl; and R 4 is hydrogen, halogen, phenyl, lower alkyl, lower alkoxyl, halo-lower alkyl, nitro or a carboxylic ester group; or R 3 and R 4 together form the residue of a benzene ring; q is zero or an integer from 1 to 12; x is an integer from 1 to 6; and Y is oxygen.
Claim 3
Dependent Claim
98 words
A compound according to claim 1 of the formula: ##SPC33## wherein: R 1 is a carboxylic acid ester converted in the human body to a carboxylic acid group; R 2 is hydrogen, lower alkyl or lower alkoxyl; R 3 is hydrogen, halogen, lower alkyl or lower alkoxyl; R 4 is hydrogen, halogen, phenyl, lower alkyl, lower alkoxyl, halo-lower alkyl, nitro, or a carboxylic ester group; or R 3 and R 4 together form the residue of a benzene ring; q is zero or an integer from 1 to 12; and s is an integer from 2 to 6.
Claim 4
Dependent Claim
130 words
A compound according to claim 1 of the formula: ##SPC34## wherein: R 1 is a carboxylic acid ester converted in the human body to a carboxylic acid group; R 2 is hydrogen, lower alkyl or lower alkoxyl; R 3 is hydrogen, halogen, lower alkyl or lower alkoxyl; and R 4 is halogen, phenyl, lower alkyl, lower alkoxyl, halo-lower alkyl, nitro or a carboxylic ester group; or R 3 is halogen, lower alkyl or lower alkoxyl; and R 4 is hydrogen, halogen, phenyl, lower alkyl, lower alkoxyl, halo-lower alkyl, nitro or a carboxylic ester group; or R 3 and R 4 together form the residue of a benzene ring; q is zero or an integer from 1 to 12; x is an integer from 1 to 6; and Y is oxygen.
Claim 5
Dependent Claim
15 words
A compound according to claim 3 wherein Q is O, and R 2 is hydrogen.
Claim 6
Dependent Claim
10 words
A compound according to claim 3 wherein x is 6.
Claim 7
Dependent Claim
13 words
The compound according to claim 5 which is: n-1-[4-ethoxycarbonylphenoxy]-6-[4'-chlorophenoxy]hexane of the formula: ##SPC35##
Claim 8
Dependent Claim
74 words
A compound according to claim 2 of the formula: ##SPC36## wherein: R 1 is a carboxylic acid ester converted in the human body to a carboxylic acid group; R 2 is hydrogen, lower alkyl or lower alkoxyl; R 3 is hydrogen, halogen, lower alkyl or lower alkoxyl; R 4 is hydrogen, halogen, phenyl, lower alkyl, lower alkoxyl, halo-lower alkyl, nitro or a carboxylic ester group; and y is an integer from 1 to 12.
Claim 9
Dependent Claim
11 words
A compound according to claim 7 wherein R 2 is hydrogen.
Claim 10
Dependent Claim
17 words
A compound according to claim 8 wherein R 3 is hydrogen and R 4 is lower alkoxyl.
Claim 11
Dependent Claim
14 words
A compound according to claim 9 which is 4-(ethoxycarbonylmethyl) phenoxy-(2'-methoxyphenyl) methane of formula: ##SPC37##
Claim 12
Dependent Claim
25 words
A compound according to claim 1 of the formula: ##SPC38## wherein R is lower alkyl, and R 4 ' is fluorine, bromine, iodine or 4-methyl.
Claim 13
Dependent Claim
11 words
A compound according to claim 1 wherein R 4 is halogen.
Claim 14
Dependent Claim
11 words
A compound according to claim 1 wherein R 4 is phenyl.
Claim 15
Dependent Claim
12 words
A compound according to claim 1 wherein R 4 is lower alkyl.
Claim 16
Dependent Claim
12 words
A compound according to claim 1 wherein R 4 is lower alkoxyl.
Claim 17
Dependent Claim
13 words
A compound according to claim 1 wherein R 4 is halo lower alkyl.
Claim 18
Dependent Claim
11 words
A compound according to claim 1 wherein R 4 is nitro.
Claim 19
Dependent Claim
14 words
A compound according to claim 1 wherein R 4 is a carboxylic ester group.
Claim 20
Dependent Claim
20 words
A compound according to claim 1 wherein R 3 and R 4 together form the residue of a benzene ring.
Claim 21
Dependent Claim
10 words
The compound according to claim 11 which is 4-ethoxycarbonylphenoxy-(4'-bromophenyl) methane.
Claim 22
Dependent Claim
10 words
The compound according to claim 11 which is 4-ethoxycarbonylphenoxy-(4'-methylphenyl) methane.
Claim 23
Dependent Claim
10 words
The compound according to claim 11 which is 4-ethoxycarbonylphenoxy-(4'-fluorophenyl) methane.
References Cited (Backward Citations)
US3166531A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-28 | 1980-03-29 | 1980-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-28 | 1984-03-29 | 1984-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-28 | 1988-03-29 | 1988-09-28 | $7700.00 | Window Closed / Lapsed |