US4439602A
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Nogalamycin derivatives
Assignee: Pharmacia and Upjohn Co
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Filing: 1981-08-20
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Granted: 1984-03-27
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Expires: 2001-08-20
Abstract
Abstract Novel N-demethyl derivatives of nogalamycin and process for preparing the same. The compounds of this invention are active against various microorganisms.
Inventors
- 👤 Paul F. Wiley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 02:34
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
100 words
A compound having the following structure: ##STR11## wherein R is selected from the group consisting of hydrogen and nogalosyl; R 1 is selected from the group consisting of hydrogen, carboxy and carbomethoxy; R 2 is selected from the group consisting of carboxylic acyl and hydrogen and B is selected from the group consisting of hydrogen and nucleophile selected from the group consisting of lower alkoxy, a sulfide anion, organic acid anion, amino, substituted amine, azide and carbanion; and carboxylic acid acylates thereof with the proviso that when R 2 is hydrogen, 9-hydroxy and the B substituent are in the con-position.
Claim 2
Dependent Claim
100 words
A compound having the following structure: ##STR11## wherein R is selected from the group consisting of hydrogen and nogalosyl; R 1 is selected from the group consisting of hydrogen, carboxy and carbomethoxy; R 2 is selected from the group consisting of carboxylic acyl and hydrogen and B is selected from the group consisting of hydrogen and nucleophile selected from the group consisting of lower alkoxy, a sulfide anion, organic acid anion, amino, substituted amine, azide and carbanion; and carboxylic acid acylates thereof with the proviso that when R 2 is hydrogen, 9-hydroxy and the B substituent are in the con-position.
Claim 3
Dependent Claim
30 words
A compound according to claim 1 wherein B is a nucleophile from a group consisting of lower alkoxy, lower alkylthioxy, lower acyloxy, lower alkylamino, azido, and bis(carbalkoxy)alkyl, alkoxyalkylamino and aminoalkylalkoxy.
Claim 4
Dependent Claim
11 words
A compound according to claim 2 wherein R 1 is carbomethoxy.
Claim 5
Dependent Claim
25 words
A compound according to claim 3 wherein R is nogalosyl, R 2 is acetyl and B is hydrogen so that the specific embodiment is N-acetyl-N-demethylnogalamycin.
Claim 6
Dependent Claim
11 words
A compound according to claim 2 wherein R 1 is hydrogen.
Claim 7
Dependent Claim
25 words
A compound according to claim 5 wherein R and R 2 are both hydrogen and B is methoxy so that the specific embodiment is 7-con-O-methyl-N-demethylnogarol.
Claim 8
Dependent Claim
25 words
A compound according to claim 5 wherein R and B are both hydrogen and R 2 is acetyl so that the specific embodiment is 7-con-O-methyl-N-acetyl-N-demethylnogarol.
Claim 9
Dependent Claim
7 words
Acylates of a compound of claim 6.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-27 | 1987-09-26 | 1988-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-27 | 1991-09-26 | 1992-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-27 | 1995-09-26 | 1996-03-27 | $7700.00 | Window Closed / Lapsed |