US4064340A
Expired / Lapsed
US
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Nogamycin and process of preparation
Assignee: Pharmacia and Upjohn Co
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Filing: 1976-12-09
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Granted: 1977-12-20
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Expires: 1996-12-09
Abstract
Abstract Novel antibiotic, nogamycin (U-51,204) prepared chemically from nogalamycinic acid. Nogamycin is active against various microorganisms, for example, Mycobacterium avium, Bacillus subtilis, Lactobacillus casei, Staphylococcus aureus, and Sarcina lutea. Thus, nogamycin can be used to inhibit the growth of the above microorganisms in various environments.
Inventors
- 👤 Paul F. Wiley
- 👤 Jian L. Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 06:55
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; A; A61; A61P; A61P31/00; A61P31/04; A61P35/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
8 words
Nogamycin, a compound having the following structure: ##STR4##
Claim 2
Dependent Claim
8 words
Nogamycin, a compound having the following structure: ##STR4##
Claim 3
Dependent Claim
40 words
Acylates of nogamycin wherein said acyl group consists of hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive; halo-, nitro-, amino-, cyano-, and lower alkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive.
Claim 4
Dependent Claim
40 words
Acylates of nogamycin wherein said acyl group consists of hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive; halo-, nitro-, amino-, cyano-, and lower alkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive.
Claim 5
Dependent Claim
23 words
A process for preparing nogamycin which comprises contacting nogalamycinic acid with dimethylformamide at a temperature of about 20° C. to about 80° C.
Claim 6
Dependent Claim
23 words
A process for preparing nogamycin which comprises contacting nogalamycinic acid with dimethylformamide at a temperature of about 20° C. to about 80° C.
Claim 7
Dependent Claim
7 words
Biologically acceptable acid addition salts of nogamycin.
Claim 8
Dependent Claim
7 words
Biologically acceptable acid addition salts of nogamycin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-19 | 1981-06-20 | 1981-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-19 | 1985-06-20 | 1985-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-19 | 1989-06-20 | 1989-12-20 | $7700.00 | Window Closed / Lapsed |