Patent US4439198A successfully refreshed from Google Patents.
US4439198A
Expired / Lapsed
US
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Biodegradable ocular insert for controlled delivery of ophthalmic medication
Assignee: University of Illinois Foundation
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Filing: 1981-07-09
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Granted: 1984-03-27
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Expires: 2001-07-09
Abstract
Abstract An ocular insert is disclosed that is attachable to the third eyelid of animals to provide controlled delivery of ophthalmic medication. The insert includes a disc impregnated with medication in controlled-release form and a biodegradable spear for attachment of the insert to the third eyelid. An insert effective for treatment of infectious bovine keratoconjunctivitis comprises a disc impregnated with chloramphenicol sodium monosuccinate and a spear of biodegradable polylactic acid which provides for retention of the insert in the eye, and consequent medication, for up to seven days.
Inventors
- 👤 II Alan H. Brightman
- 👤 Michael C. Theodorakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 09:08
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61F; A61F9/00; A61F9/0008; A61F9/0017
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
93 words
An ocular insert adapted for attachment to the third eyelid of a mammalian animal comprising a substantially disc-shaped reservoir impregnated with an ophthalmic drug in amount and form to provide continuous, controlled administration of a pre-determined, therapeutically effective dosage of drug to the eye over a prolonged period of time; and a fixed spear of biodegradable material protruding from the reservoir for piercing the third eyelid and attaching the insert thereto, said biodegradable material being selected from the group consisting of polylactic acid, polylactic glyconic acid, polysaccharide derivatives, polyaminoacids, cellulose, and ethyl cellulose.
Claim 2
Dependent Claim
93 words
An ocular insert adapted for attachment to the third eyelid of a mammalian animal comprising a substantially disc-shaped reservoir impregnated with an ophthalmic drug in amount and form to provide continuous, controlled administration of a pre-determined, therapeutically effective dosage of drug to the eye over a prolonged period of time; and a fixed spear of biodegradable material protruding from the reservoir for piercing the third eyelid and attaching the insert thereto, said biodegradable material being selected from the group consisting of polylactic acid, polylactic glyconic acid, polysaccharide derivatives, polyaminoacids, cellulose, and ethyl cellulose.
Claim 3
Dependent Claim
49 words
The ocular insert of claim 1 wherein the reservoir consists essentially of an organic polymer selected from the group consisting of polyolefins, polyesters, polylactic acid, polylactic glyconic acid, polysaccharide derivatives, polyaminoacids, cellulose, and ethyl cellulose, said organic polymer being impregnated with a therapeutically effective amount of an ophthalmic drug.
Claim 4
Dependent Claim
27 words
The ocular insert of claim 1 wherein both the reservoir and the spear comprise polylactic acid having a molecular weight of from about 50,000 to about 60,000.
Claim 5
Dependent Claim
21 words
The ocular insert of claim 3 wherein the ophthalmic drug is selected from the group consisting of chloramphenicol and oxytetracycline hydrochloride.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-27 | 1987-09-26 | 1988-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-27 | 1991-09-26 | 1992-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-27 | 1995-09-26 | 1996-03-27 | $7700.00 | Window Closed / Lapsed |