US4438261A
Expired / Lapsed
US
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Anticoagulant substance
Assignee: Riker Laboratories Inc
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Filing: 1982-06-01
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Granted: 1984-03-20
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Expires: 2002-06-01
Abstract
Abstract Partially depolymerized heparin products having particular analyzable reducing end groups, a process for their preparation and their use as anticoagulants and antithrombotics.
Inventors
- 👤 William E. Barnett
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:13
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
62 words
A chemically partially depolymerized heparin product which has (1) a weight average molecular weight of from about 2,000 to 4,000 daltons, when determined by HPLC using 1.5 molar aqueous sodium chloride as the mobile phase and dextrans as the standard, (2) a polydispersity (D) of less than about 2.5, and (3) analyzable reducing end groups of which a majority are anhydromannose groups.
Claim 2
Dependent Claim
62 words
A chemically partially depolymerized heparin product which has (1) a weight average molecular weight of from about 2,000 to 4,000 daltons, when determined by HPLC using 1.5 molar aqueous sodium chloride as the mobile phase and dextrans as the standard, (2) a polydispersity (D) of less than about 2.5, and (3) analyzable reducing end groups of which a majority are anhydromannose groups.
Claim 3
Dependent Claim
29 words
A heparin product according to claim 1 wherein the analyzable reducing end groups are selected from anhydromannose, iduronic acid and glucuronic acid of which about 51-90 percent are anhydromannose.
Claim 4
Dependent Claim
21 words
A method for inhibiting the coagulation of which comprises mixing a chemically partially depolymerized heparin according to claim 1 with blood.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |