Patent US4438198A successfully refreshed from Google Patents.
US4438198A
Expired / Lapsed
US
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Biochemically active matrix for use in a bio-artificial organ
Assignee: BIOMEDICS Inc AN IL CORP
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Filing: 1981-09-30
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Granted: 1984-03-20
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Expires: 2001-09-30
Abstract
Abstract A biochemically active matrix for use in a bio-artificial organ is disclosed. The biochemically active matrix has an enzyme covalently bonded to a matrix of organochemically cross-linked fibrin. The matrix may be suspended in a medium of agarose which irreversibly solidifies below 37° C. The bio-artificial organ is useful for extracorporeal treatment of blood to remove excess substrate from the blood. .
Inventors
- 👤 Gottfried Schmer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:22
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/10
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
59 words
A biochemically active matrix suitable for use in a bio-artificial organ comprising at least one biochemically active enzyme covalently bonded to the surface of a carrier matrix of organochemically cross-linked fibrin through a reactive group of the enzyme which is not essential for its enzymatic activity and suspended in a medium of agarose which irreversibly solidifies below 37° C.
Claim 2
Dependent Claim
59 words
A biochemically active matrix suitable for use in a bio-artificial organ comprising at least one biochemically active enzyme covalently bonded to the surface of a carrier matrix of organochemically cross-linked fibrin through a reactive group of the enzyme which is not essential for its enzymatic activity and suspended in a medium of agarose which irreversibly solidifies below 37° C.
Claim 3
Dependent Claim
23 words
The biochemically active matrix of claim 1 wherein the biochemically active enzyme is covalently bonded to the surface of the matrix by glutaraldehyde.
Claim 4
Dependent Claim
14 words
The biochemically active matrix of claim 1 wherein the biochemically active enzyme is L-asparaginase.
Claim 5
Dependent Claim
14 words
The biochemically active matrix of claim 1 wherein the biochemically active enzyme is urease.
Claim 6
Dependent Claim
14 words
The biochemically active matrix of claim 1 wherein the biochemically active enzyme is indolyl-3-alkane-α-hydroxylase.
Claim 7
Dependent Claim
18 words
The biochemically active matrix of claim 1 wherein said enzyme is asparaginase and is covalently bonded by glutaraldehyde.
Claim 8
Dependent Claim
88 words
A bio-artificial organ comprising: (a) a reactor housing defining an enclosed space with an inlet and an outlet, the inner surface of the housing being compatible with an extracorporeal blood flow; (b) a carrier matrix of organochemically cross-linked fibrin disposed within the reactor, said carrier matrix being suspended in a medium of agarose which gels irreversibly below 37° C.; and (c) a biochemically active enzyme covalently bonded to the surface of the matrix through a reactive group of the enzyme which is not essential for its enzymatic activity.
Claim 9
Dependent Claim
88 words
A bio-artificial organ comprising: (a) a reactor housing defining an enclosed space with an inlet and an outlet, the inner surface of the housing being compatible with an extracorporeal blood flow; (b) a carrier matrix of organochemically cross-linked fibrin disposed within the reactor, said carrier matrix being suspended in a medium of agarose which gels irreversibly below 37° C.; and (c) a biochemically active enzyme covalently bonded to the surface of the matrix through a reactive group of the enzyme which is not essential for its enzymatic activity.
Claim 10
Dependent Claim
22 words
The bio-artificial organ of claim 7 wherein the biochemically active enzyme is covalently bonded to the surface of the matrix by glutaraldehyde.
Claim 11
Dependent Claim
12 words
The bio-artificial organ of claim 7 the biochemically active enzyme is L-asparaginase.
Claim 12
Dependent Claim
17 words
The bio-artificial organ of claim 7 wherein the carrier matrix is disposed on a physical support means.
References Cited (Backward Citations)
US3639558A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |