US4438098A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Heat treatment of a non-A, non-B hepatitis agent to prepare a vaccine
Assignee: United States Department of Health and Human Services
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Filing: 1982-01-27
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Granted: 1984-03-20
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Expires: 2002-01-27
Abstract
Abstract A method of treating the agent of human non-A, non-B hepatitis to render it incapable of causing infection which comprises heating said agent at about 60° C. for about 10 hours and recovering the treated protective agent. Furthermore, this treated agent may be utilized as a vaccine, as, for example, inoculating chimpanzees by i.v. inoculation with the heat treated non-A, non-B agent and the animals have been found protected from later challenge by non-A, non-B hepatitis agent. Thus, the second part of the invention resides in the utilization of a heat-treated agent from human plasma later utilized to protect chimpanzees by incoluation and utilization as a vaccine.
Inventors
- 👤 Edward Tabor
- 👤 Robert J. Gerety
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 08:42
CPC Classifications
C; C12; C12N; C12N7/00; A; A61; A61K; A61K39/00; A61K39/12; A61K39/29; A61K2039/51; A61K2039/525; A61K2039/5252; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24211; C12N2770/24234; C12N2770/24261
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
43 words
A method of treating the agent of human non-A, non-B hepatitis to render it incapable of causing infection which consists essentially of heating said agent contained in serum or plasma at about 60° C. for about 10 hours and recovering said treated agent.
Claim 2
Independent Claim
43 words
A method of treating the agent of human non-A, non-B hepatitis to render it incapable of causing infection which consists essentially of heating said agent contained in serum or plasma at about 60° C. for about 10 hours and recovering said treated agent.
Claim 3
Dependent Claim
39 words
A method of producing a vaccine which comprises inoculating chimpanzees with an agent prepared according to claim 1 and thereby protecting from later challenge by a non-A, non-B hepatitis agent and workup and recovery of antibodies to said vaccine.
References Cited (Backward Citations)
US4291020A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-03-20 | 1987-09-19 | 1988-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-03-20 | 1991-09-19 | 1992-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-03-20 | 1995-09-19 | 1996-03-20 | $7700.00 | Window Closed / Lapsed |