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Ionic opthalmic cellulose polymer solutions

Assignee: PTC LIQUIDATING Corp
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Filing: 1981-11-09
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Granted: 1984-03-13
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Expires: 2001-11-09
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Abstract

Abstract A contact lens solution is provided for wetting, soaking and lubricating of hard contact lenses, particularly those carrying an ionic charge. The solution contains an ionic polymer of cationic or anionic charge that interacts with an oppositely charged surface of a contact lens forming an interfacial polyelectrolyte complex. This polyelectrolyte complex provides increased, long lasting lens wettability leading to a cushioning and lubricating effect with the eyelid and the cornea.

Inventors

  • 👤 Edward J. Ellis
  • 👤 Joseph C. Salamone

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-25 03:30
CPC Classifications
A; A61; A61L; A61L12/00; A61L12/08; A61K; A61K31/00; A61K31/74; A61K9/00; A61K9/0012; A61K9/0048; G; G02; G02C; G02C7/00; G02C7/02; G02C7/04

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 294 words
A lens solution for treating contact lens surfaces to form a protective coating thereof, said lens solution consisting essentially of a cationic cellulose polymer in solution with said polymer being present in an amount of from 0.001 to 10% by weight of said solution, said solution being useful to form protective coatings on lens surfaces formed of oppositely charged material by producing a thin coating of a hydrogel when contacted with said contact lens surface, said lens solution having a pH in the range of from 6 to 8, said polymer having the following formula: ##STR14## where R 1 , R 2 and R 3 are selected from the group consisting essentially of H, derivatives of C 1 -C 20 carboxylic acid, C 1 -C 20 alkyl groups, C 1 to C 3 monohydric and dihydric alkanols, hydroxyethyl groups, hydroxypropyl groups, ethylene oxide groups, propylene oxide groups, phenyl groups, "Z" groups and combinations thereof, Z being selected from cationic groups, said cationic groups being selected from groups as follows: A. groups containing nitrogen ##STR15## where: R', R" and R'" can be H, CH 3 , C 2 H 5 , CH 2 CH 2 OH, or ##STR16## x=0-5, y=0-4, and z=0-5 X - =Cl - , Br - , I - , HSO 4 - , CH 3 SO 4 - , H 2 PO 4 - , NO 3 - B. Groups containing phosphorous ##STR17## where: R', R" and R'" can be H, CH 3 , C 2 H 5 , CH 2 CH 2 OH, or ##STR18## x=0-5, y=0-4 and z=0-5 X - =Cl - , Br - , I - , HSO 4 - , CH 3 SO 4 - , H 2 PO 4 - , NO 3 - .
Claim 2
Dependent Claim 294 words
A lens solution for treating contact lens surfaces to form a protective coating thereof, said lens solution consisting essentially of a cationic cellulose polymer in solution with said polymer being present in an amount of from 0.001 to 10% by weight of said solution, said solution being useful to form protective coatings on lens surfaces formed of oppositely charged material by producing a thin coating of a hydrogel when contacted with said contact lens surface, said lens solution having a pH in the range of from 6 to 8, said polymer having the following formula: ##STR14## where R 1 , R 2 and R 3 are selected from the group consisting essentially of H, derivatives of C 1 -C 20 carboxylic acid, C 1 -C 20 alkyl groups, C 1 to C 3 monohydric and dihydric alkanols, hydroxyethyl groups, hydroxypropyl groups, ethylene oxide groups, propylene oxide groups, phenyl groups, "Z" groups and combinations thereof, Z being selected from cationic groups, said cationic groups being selected from groups as follows: A. groups containing nitrogen ##STR15## where: R', R" and R'" can be H, CH 3 , C 2 H 5 , CH 2 CH 2 OH, or ##STR16## x=0-5, y=0-4, and z=0-5 X - =Cl - , Br - , I - , HSO 4 - , CH 3 SO 4 - , H 2 PO 4 - , NO 3 - B. Groups containing phosphorous ##STR17## where: R', R" and R'" can be H, CH 3 , C 2 H 5 , CH 2 CH 2 OH, or ##STR18## x=0-5, y=0-4 and z=0-5 X - =Cl - , Br - , I - , HSO 4 - , CH 3 SO 4 - , H 2 PO 4 - , NO 3 - .
Claim 3
Dependent Claim 25 words
A lens solution in accordance with claim 1 wherein said polymer is a cellulose polymer containing quaternary amino groups along the chain of the polymer.
Claim 4
Dependent Claim 62 words
In combination a sterile lens solution for treating contact lens surfaces and a contact lens, said lens solution consisting essentially of a cationic cellulosic polymer in water solution with said polymer being present in an amount of from 0.001 to 10% by weight of said solution, said solution being sterile and having a physiologically-acceptable pH, said contact lens having a charged surface.
Claim 5
Dependent Claim 62 words
In combination a sterile lens solution for treating contact lens surfaces and a contact lens, said lens solution consisting essentially of a cationic cellulosic polymer in water solution with said polymer being present in an amount of from 0.001 to 10% by weight of said solution, said solution being sterile and having a physiologically-acceptable pH, said contact lens having a charged surface.

References Cited (Backward Citations)

US3954965A Cited
US4343787A Cited
US4039662A Cited
US4321261A Cited
US4287175A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1987-03-13 1987-09-12 1988-03-13 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1991-03-13 1991-09-12 1992-03-13 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1995-03-13 1995-09-12 1996-03-13 $7700.00 Window Closed / Lapsed

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