Patent US4434151A successfully refreshed from Google Patents.
US4434151A
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Bifunctional chelating agents
Assignee: Medi Physics Inc
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Filing: 1982-11-08
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Granted: 1984-02-28
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Expires: 2002-11-08
Abstract
Abstract Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a radiodiagnostic agent for use in in vivo imaging and a method for producing this chelating agent.
Inventors
- 👤 Edmund F. Byrne
- 👤 Glen L. Tolman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:49
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
57 words
An anionic chelate of the formula: ##STR10## wherein R 6 is lower alkyl R 1 and R 2 are individually hydrogen or lower alkyl or taken together form oxo; M is a radioactive metal; R 4 is hydrogen or lower alkyl; x and y are integers from 0 to 2 or a salt of said anionic chelate.
Claim 2
Dependent Claim
57 words
An anionic chelate of the formula: ##STR10## wherein R 6 is lower alkyl R 1 and R 2 are individually hydrogen or lower alkyl or taken together form oxo; M is a radioactive metal; R 4 is hydrogen or lower alkyl; x and y are integers from 0 to 2 or a salt of said anionic chelate.
Claim 3
Dependent Claim
16 words
The chelate of claim 1 wherein M is selected from the group consisting of radioactive technetium.
Claim 4
Dependent Claim
9 words
The chelate of claim 1 wherein M is technetium-99m.
Claim 5
Dependent Claim
11 words
The chelate of claim 3 wherein said chelate is [2-[[1-(2-mercaptoethyl)-2-(methylamino)-2-oxoethyl]amino]-N-(2-mercaptoethyl)glycinato N,N'S,S']oxotechnetate-99m.
Claim 6
Dependent Claim
22 words
The chelate of claim 4 wherein said chelate is in the form of its alkali metal salt, ammonium salt or amine salts.
Claim 7
Dependent Claim
10 words
The chelate of claim 1 wherein said chelate is [1-[[1-(2-mercaptoethyl)-2-(methylamino)-2-oxoethyl]amino]-N-(2-mercapto-1,1-oxopropyl)glycinato-N,N',S,S']oxotechnetate-99m.
Claim 8
Dependent Claim
89 words
A process for imaging organs comprising intravenously injecting an effective amount of a composition containing an anionic chelate of the formula: ##STR11## wherein R 6 is lower alkyl R 1 and R 2 are individually hydrogen or lower alkyl or taken together form oxo; M is a radioactive metal; R 4 is hydrogen or lower alkyl; x and y are integers from 0 to 2 or a salt of said chelate in a carrier suitable for intravenous injection and scanning the organ to be imaged with a scintiscanning means.
Claim 9
Dependent Claim
89 words
A process for imaging organs comprising intravenously injecting an effective amount of a composition containing an anionic chelate of the formula: ##STR11## wherein R 6 is lower alkyl R 1 and R 2 are individually hydrogen or lower alkyl or taken together form oxo; M is a radioactive metal; R 4 is hydrogen or lower alkyl; x and y are integers from 0 to 2 or a salt of said chelate in a carrier suitable for intravenous injection and scanning the organ to be imaged with a scintiscanning means.
Claim 10
Dependent Claim
9 words
The process of claim 7 wherein M is technetium-99m.
Claim 11
Dependent Claim
11 words
The process of claim 7 wherein said chelate is [2-[[1-(2-mercaptoethyl)-2-(methylamino)-2-oxoethyl]amino]-N-(2-mercaptoethyl)glycinato N,N',S,S']oxotechnetate-99m.
Claim 12
Dependent Claim
10 words
The process of claim 8 wherein said chelate is [1-[[1-(2-mercaptoethyl)-2-(methylamino)-2-oxoethyl]amino]-N-(2-mercapto-1,1-oxopropyl)glycinato-N,N',S,S']oxotechnetate-99m.
Claim 13
Dependent Claim
98 words
A composition suitable for intravenous injection comprising an anionic chelate of the formula: ##STR12## wherein R is hydrogen or lower alkyl; R 6 is lower alkyl R 1 and R 2 are individually hydrogen or lower alkyl or taken together form oxo; M is a radioactive metal; R 4 is hydrogen or lower alkyl; x and y are integers from 0 to 2 or a salt of said anionic chelate said chelate or said salt being present in an amount sufficient to provide radioactivity of from 101 mCi to 100 mCi and a carrier suitable for intravenous injection.
Claim 14
Dependent Claim
98 words
A composition suitable for intravenous injection comprising an anionic chelate of the formula: ##STR12## wherein R is hydrogen or lower alkyl; R 6 is lower alkyl R 1 and R 2 are individually hydrogen or lower alkyl or taken together form oxo; M is a radioactive metal; R 4 is hydrogen or lower alkyl; x and y are integers from 0 to 2 or a salt of said anionic chelate said chelate or said salt being present in an amount sufficient to provide radioactivity of from 101 mCi to 100 mCi and a carrier suitable for intravenous injection.
Claim 15
Dependent Claim
10 words
The composition of claim 12 wherein said chelate is [2-[[1-(2-mercaptoethyl)-2-(methylamino)-2-oxoethyl]amino]-N-(2-mercaptoethyl)glycinato-N,N'S,S']oxotechnetate-99m.
Claim 16
Dependent Claim
10 words
The composition of claim 12 wherein said chelate is [1-[[1-(2-mercaptoethyl)-2-(methylamino)-2-oxoethyl]amino]-N-(2-mercapto-1,1-oxopropyl)glycinato-N,N',S,S']oxotechnetate-99m.
References Cited (Backward Citations)
US4118468A
Cited
US4255443A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1987-02-27 | 1987-08-29 | 1988-02-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-27 | 1991-08-29 | 1992-02-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-27 | 1995-08-29 | 1996-02-28 | $7700.00 | Window Closed / Lapsed |