Patent US4432366A successfully refreshed from Google Patents.
US4432366A
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Reference electrode catheter
Assignee: SENTRON VOF OOSTEINDE 8 9301 LJ RODEN NETHERLANDS A CORP OF NETHERLANDS
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Filing: 1981-11-27
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Granted: 1984-02-21
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Expires: 2001-11-27
Abstract
Abstract A reference electrode catheter for use for in vivo measurement of body fluids. The catheter includes a small diameter cylindrical tube having a reference electrode assembly disposed on the distal end thereof. The reference electrode assembly includes a hollow cylindrical housing and an electrode element positioned within the housing mounted on and supported by a retainer member. The electrode element is connected to an electrical conductor which extends out of the housing and through the passageway of the tubing to the proximal end of the tubing. An electrolytic material, such as gelled Ringer's solution, is disposed within the housing, and a membrane formed of hydrogel is positioned across an aperture in the housing so as to form an ion diffusion barrier between the body fluids to be measured and the electrolytic material within the housing.
Inventors
- 👤 Gary S. Margules
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 11:28
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14542; A61B5/1468; A61B5/1473
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
197 words
A reference electrode catheter for use in potentiometric electroanalysis in body fluids comprising: an elongated cylindrical tubing having proximal and distal ends and having a passageway extending throughout the entire length thereof; a hollow cylindrical housing member being mounted at the distal end of said tubing and having enclosed ends to thereby form a sealed chamber within said housing member, an aperture extending through a wall of said housing member and communicating with said chamber; an electrode positioned within said chamber; a conductive lead connected to said electrode and extending out of the housing member and through said passageway of said tubing to the proximal end of said tubing; retainer means positioned within said housing member for supporting said electrode; electrolytic material disposed within the chamber of the cylindrical housing member and in contact with said electrode; and, a biocompatible porous liquid junction comprised of a hydrogel being positioned across said aperture in said housing member so as to form an ion diffusion control barrier between body fluids and the electrolytic material within the chamber in said housing member for providing a stable liquid junction potential in body fluids to provide a substantially voltage stable reference electrode.
Claim 2
Dependent Claim
197 words
A reference electrode catheter for use in potentiometric electroanalysis in body fluids comprising: an elongated cylindrical tubing having proximal and distal ends and having a passageway extending throughout the entire length thereof; a hollow cylindrical housing member being mounted at the distal end of said tubing and having enclosed ends to thereby form a sealed chamber within said housing member, an aperture extending through a wall of said housing member and communicating with said chamber; an electrode positioned within said chamber; a conductive lead connected to said electrode and extending out of the housing member and through said passageway of said tubing to the proximal end of said tubing; retainer means positioned within said housing member for supporting said electrode; electrolytic material disposed within the chamber of the cylindrical housing member and in contact with said electrode; and, a biocompatible porous liquid junction comprised of a hydrogel being positioned across said aperture in said housing member so as to form an ion diffusion control barrier between body fluids and the electrolytic material within the chamber in said housing member for providing a stable liquid junction potential in body fluids to provide a substantially voltage stable reference electrode.
Claim 3
Dependent Claim
18 words
A catheter as defined in claim 1 wherein said hydrogel biocompatible porous liquid junction is formed of poly(hydroxethylmethacrylate).
Claim 4
Dependent Claim
42 words
A catheter as defined in claim 1 wherein said hydrogel biocompatible porous liquid junction is comprised of a selected one of the group consisting of: poly(hydroxyethylmethacrylate), poly(glyceryl methacrylate), poly(hydroxypropyl methacrylate), poly(hydroxyethoxyethyl methacrylate poly(hydroxydiethoxyethyl methacrylate), poly(methoxyethyl methacrylate), poly(methoxyethoxyethyl methacrylate), poly(methoxydiethoxyethyl methacrylate), poly(2,3-dihydroxypropyl methacrylate).
Claim 5
Dependent Claim
89 words
A catheter as defined in claim 1 wherein said elongated cylindrical tubing has a second passageway extending throughout the entire length thereof, the second passageway being positioned such that the distal end of the passageway is disposed in proximity to an outer surface of the hydrogel biocompatible porous liquid junction so that fluid passing through said second passageway in a direction from the proximal end to the distal end of the elongated cylindrical tubing provides a flushing action across the outer surface of the hydrogel biocompatible porous liquid junction.
Claim 6
Dependent Claim
15 words
A catheter as defined in claim 4 wherein said electrolytic material is gelled Ringer's solution.
Claim 7
Dependent Claim
15 words
A catheter as defined in claim 1 wherein said electrolytic material is gelled Ringer's solution.
Claim 8
Dependent Claim
17 words
The catheter of claim 1 wherein said aperture is in a side wall of said housing member.
Claim 9
Dependent Claim
17 words
The catheter of claim 1 wherein said electrode is made, at least in part, of silver/silver chloride.
Claim 10
Dependent Claim
155 words
A reference electrode assembly for potentiometric electroanalysis in body fluids comprising: a hollow cylindrical housing member having enclosed ends to thereby form a sealed chamber within said housing member, an aperture extending through a wall of said housing member and communicating with said chamber; an electrode positioned within the chamber; a conductive lead connected to the electrode and extending out of the housing member; retainer means positioned within said housing member for supporting said electrode; electrolytic material disposed within the chamber of the cylindrical housing member and in contact with said electrode; and a biocompatible porous liquid junction comprised of a hydrogel being positioned across said aperture in said housing member so as to form an ion diffusion control barrier between body fluids to be measured and the electrolytic material within the chamber in said housing member for providing a stable liquid junction potential in body fluids to provide a substantially voltage stable reference electrode.
Claim 11
Dependent Claim
155 words
A reference electrode assembly for potentiometric electroanalysis in body fluids comprising: a hollow cylindrical housing member having enclosed ends to thereby form a sealed chamber within said housing member, an aperture extending through a wall of said housing member and communicating with said chamber; an electrode positioned within the chamber; a conductive lead connected to the electrode and extending out of the housing member; retainer means positioned within said housing member for supporting said electrode; electrolytic material disposed within the chamber of the cylindrical housing member and in contact with said electrode; and a biocompatible porous liquid junction comprised of a hydrogel being positioned across said aperture in said housing member so as to form an ion diffusion control barrier between body fluids to be measured and the electrolytic material within the chamber in said housing member for providing a stable liquid junction potential in body fluids to provide a substantially voltage stable reference electrode.
Claim 12
Dependent Claim
18 words
A reference electrode assembly as defined in claim 9 wherein said hydrogel biocompatible porous liquid junction is poly(hydroxyethylmethacrylate).
Claim 13
Dependent Claim
44 words
A reference electrode assembly as defined in claim 9 wherein said hydrogel biocompatible porous liquid junction is comprised of a selected one of the group consisting of: poly(hydroxyethylmethacrylate), poly(glyceryl methacrylate), poly(hydroxypropyl methacrylate), poly(hydroxyethoxyethyl) methacrylate, poly(hydroxydiethoxyethyl methacrylate), poly(methoxyethyl methacrylate), poly(methoxyethoxyethyl methacrylate), poly(methoxydiethoxyethyl methacrylate), poly(2,3-dihydroxypropyl methacrylate).
Claim 14
Dependent Claim
17 words
A reference electrode assembly as defined in claim 9 wherein said electrolytic material is gelled Ringer's solution.
Claim 15
Dependent Claim
53 words
A reference electrode assembly as defined in claim 9 wherein said biocompatible porous liquid junction is comprised of hydrogel formed by polymerizing a selected one from the group of monomers comprising: hydroxyalkyl methacrylate, acrylamide derivatives, n-vinyl pyrrolidene, hydrophobic acrylics, acrylic acid derivatives, crotonic acid, sodium styrene sulfonate, aminoethyl methacrylate derivatives and vinyl pyridine.
Claim 16
Dependent Claim
19 words
The reference electrode assembly of claim 9 wherein said aperture is in a side wall of said housing member.
Claim 17
Dependent Claim
19 words
The reference electrode assembly of claim 9 wherein said electrode is made, at least in part, of silver/silver chloride.
Claim 18
Dependent Claim
57 words
A reference electrode assembly as defined in claim 9 combined with a catheter connected to said housing member and comprising a cylindrical tubing having proximal and distal ends and having a passageway extending throughout the entire length thereof and wherein said conductive lead extends through said passageway throughout the length of said lead to said housing member.
Claim 19
Dependent Claim
92 words
A reference electrode assembly and catheter combination as defined in claim 16 wherein said cylindrical tubing has a second passageway extending throughout the entire length thereof, the second passageway being positioned such that the distal end of the passageway is disposed in proximity to an outer surface of the hydrogel biocompatible porous liquid junction so that fluid passing through said second passageway in a direction from the proximal end to the distal end of the cylindrical tubing provides a flushing action across the outer surface of the hydrogel biocompatible porous liquid junction.
Claim 20
Dependent Claim
20 words
A reference electrode assembly and catheter combination as defined in claim 17 wherein said electrolytic material is gelled Ringer's solution.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-20 | 1987-08-22 | 1988-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-20 | 1991-08-22 | 1992-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-20 | 1995-08-22 | 1996-02-21 | $7700.00 | Window Closed / Lapsed |