US4431626A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tc-99m Labeled carrier for imaging
Assignee: University of California
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Filing: 1981-05-27
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Granted: 1984-02-14
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Expires: 2001-05-27
Abstract
Abstract Novel radionuclide imaging agents, having particular application for lymphangiography are provided by non-covalently binding Tc-99m to a pharmaceutically acceptable cross-linked polysaccharide. Upon injection of the Tc-99m labeled polysaccharide into the blood stream, optimum contrast can be obtained within one hour.
Inventors
- 👤 Eberhard Henze
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:16
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/06; A61K2123/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
31 words
A reagent useful for the reduction of pertechnetate comprising stannous chloride and a pharmaceutically acceptable water soluble dextran of at least about 25,000 molecular weight in a pharmaceutically acceptable aqueous vehicle.
Claim 2
Dependent Claim
31 words
A reagent useful for the reduction of pertechnetate comprising stannous chloride and a pharmaceutically acceptable water soluble dextran of at least about 25,000 molecular weight in a pharmaceutically acceptable aqueous vehicle.
Claim 3
Dependent Claim
43 words
A composition according to claim 1, wherein said dextran of from about 25,000 to 5,000,000 molecular weight present in an amount of from about 5 to 20 weight percent and said stannous chloride is present in from about 5 to 25 weight percent.
Claim 4
Dependent Claim
26 words
A composition according to claim 2, wherein the weight ratio of stannous chloride to dextran is 0.2-5:1 and said vehicle is a pharmaceutically acceptable saline solution.
Claim 5
Dependent Claim
59 words
A radioimaging reagent comprising Tc-99m bound to a water soluble dextran of at least about 25,000 molecular weight by in situ reduction of pertechnetate in the presence of said dextran, wherein said in situ reduction comprises: contacting said pertechnetate with stannous chloride at a weight ratio of about 1-2:1 and at a pH in the range of about 1-4.
Claim 6
Dependent Claim
59 words
A radioimaging reagent comprising Tc-99m bound to a water soluble dextran of at least about 25,000 molecular weight by in situ reduction of pertechnetate in the presence of said dextran, wherein said in situ reduction comprises: contacting said pertechnetate with stannous chloride at a weight ratio of about 1-2:1 and at a pH in the range of about 1-4.
Claim 7
Dependent Claim
17 words
An imaging reagent according to claim 4, wherein said dextran of from about 40,000 to 2,000,000 daltons.
Claim 8
Independent Claim
87 words
A method for radioimaging in a host, which comprises injecting Tc-99m bound to a water soluble dextran of at least about 25,000 molecular weight by in situ reduction of pertechnetate in the presence of said dextran, in a pharmaceutically acceptable vehicle in an amount sufficient to provide imaging contrast for an organ of interest, wherein said in situ reduction comprises: combining stannous chloride with said pertechnetate at a weight ratio of about 1-2:1 of stannous chloride to dextran at a pH in the range from about 1-4.
Claim 9
Independent Claim
87 words
A method for radioimaging in a host, which comprises injecting Tc-99m bound to a water soluble dextran of at least about 25,000 molecular weight by in situ reduction of pertechnetate in the presence of said dextran, in a pharmaceutically acceptable vehicle in an amount sufficient to provide imaging contrast for an organ of interest, wherein said in situ reduction comprises: combining stannous chloride with said pertechnetate at a weight ratio of about 1-2:1 of stannous chloride to dextran at a pH in the range from about 1-4.
Claim 10
Dependent Claim
17 words
A method according to claim 6, wherein said dextran is from about 40,000 to 2,000,000 molecular weight.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-13 | 1987-08-15 | 1988-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-13 | 1991-08-15 | 1992-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-13 | 1995-08-15 | 1996-02-14 | $7700.00 | Window Closed / Lapsed |