US4002730A
Expired / Lapsed
US
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Radionuclide carriers
Assignee: Procter and Gamble Co
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Filing: 1975-01-13
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Granted: 1977-01-11
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Expires: 1995-01-13
Abstract
Abstract Physiologically acceptable particulate radionuclide carriers comprising a reducing agent bound to an anionic starch derivative, useful in the preparation of organ-specific diagnostic radiopharmaceuticals.
Inventors
- 👤 Frederick Anthony Hartman
- 👤 Herbert Charles Kretschmar
- 👤 Andrew John Tofe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 06:17
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1241; A61K51/02; A61K51/025; A61K51/04; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
46 words
A physiologically acceptable, substantially water-insoluble particulate radionuclide carrier comprising an anionic starch derivative comprising from about 1% to about 20% by weight anionic substituents, wherein an average of from about 0.1% to about 1.5%, by weight, of a reducing agent is bound to said starch derivative.
Claim 2
Dependent Claim
46 words
A physiologically acceptable, substantially water-insoluble particulate radionuclide carrier comprising an anionic starch derivative comprising from about 1% to about 20% by weight anionic substituents, wherein an average of from about 0.1% to about 1.5%, by weight, of a reducing agent is bound to said starch derivative.
Claim 3
Dependent Claim
33 words
A radionuclide carrier according to claim 1, wherein the anionic substituent is a member selected from the group consisting of anions of phosphoric acid, phosphonic acid, pyrophosphoric acid, polyphosphoric acid, and polyphosphonic acid.
Claim 4
Dependent Claim
15 words
A radionuclide carrier according to claim 2, wherein said anionic substituent is the phosphate ion.
Claim 5
Dependent Claim
25 words
A radionuclide carrier according to claim 1, wherein said reducing agent is selected from the group consisting of the ferrous, cuprous, chromous, and stannous ions.
Claim 6
Dependent Claim
15 words
A radionuclide carrier according to claim 4, wherein said reducing agent is the stannous ion.
Claim 7
Dependent Claim
25 words
A radionuclide carrier according to claim 1 wherein the reducing agent is present in an amount of from about 0.2% to about 0.8% by weight.
Claim 8
Dependent Claim
52 words
A radiolabeled scintigraphic agent comprising a physiologically acceptable particulate water-insoluble radionuclide carrier comprising an average of from about 0.1% to about 1.5%, by weight, of a reducing agent bound to an anionic starch derivative having an average of from about 1% to about 20%, by weight, of anionic substituent, and a radionuclide.
Claim 9
Dependent Claim
52 words
A radiolabeled scintigraphic agent comprising a physiologically acceptable particulate water-insoluble radionuclide carrier comprising an average of from about 0.1% to about 1.5%, by weight, of a reducing agent bound to an anionic starch derivative having an average of from about 1% to about 20%, by weight, of anionic substituent, and a radionuclide.
Claim 10
Dependent Claim
12 words
A scintigraphic agent according to claim 7, wherein said radionuclide is technetium-99m.
Claim 11
Dependent Claim
45 words
A physiologically acceptable, substantially water-insoluble particulate radionuclide carrier according to claim 6 comprising from about 0.2% to about 0.8%, by weight, of stannous cation bound to an anionic starch derivative having an average of from about 4% to about 5%, by weight, of phosphate substituents.
Claim 12
Dependent Claim
53 words
A radiolabeled scintigraphic agent according to claim 8 wherein the radionuclide carrier comprises an anionic starch derivative which comprises phosphorylated starch containing from about 4% to about 5% by weight of phosphate substituents, and the reducing agent bound to said phosphorylated starch comprises from about 0.2% to about 0.8% by weight of tin.
Claim 13
Dependent Claim
26 words
A composition according to claim 10 wherein the radionuclide carrier has an average particle size in the range from about 10 microns to about 45 microns.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-11 | 1980-07-12 | 1981-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-11 | 1984-07-12 | 1985-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-11 | 1988-07-12 | 1989-01-11 | $7700.00 | Window Closed / Lapsed |