Patent US4430260A successfully refreshed from Google Patents.
US4430260A
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Penicillin-polyvinyl alcohol conjugate and process of preparation
Assignee: Individual
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Filing: 1981-10-19
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Granted: 1984-02-07
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Expires: 2001-10-19
Abstract
Abstract This invention relates to tolerogenic conjugates, suitable for use in suppressing the formation of reaginic antibodies in a host, of haptenic determinants, in particular the benzylpenicilloyl (BPO) group and 2,4-dinitrophenyl (DNP) group, with water-soluble, nonimmunogenic polymers, i.e. polyvinyl alcohols (PVA). The invention also comprises a method for the preparation of the conjugate and a method of suppressing the formation of these antibodies in a mammal sensitive to penicillin.
Inventors
- 👤 Weng Y. Lee
- 👤 Alec Sehon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:19
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/385; A61K2039/60; A61K2039/6093; A61K38/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
55 words
A process for the preparation of nonimmunogenic conjugates, suitable for suppressing the formation of reaginic antibodies to penicillin (BPO) in a host, the said conjugate being prepared by the reaction of penicillin G in the presence of a suitable salt, at alkaline pH, with an amino derivative of the water-soluble, nonimmunogenic polymer, polyvinyl alcohol (PVA).
Claim 2
Dependent Claim
55 words
A process for the preparation of nonimmunogenic conjugates, suitable for suppressing the formation of reaginic antibodies to penicillin (BPO) in a host, the said conjugate being prepared by the reaction of penicillin G in the presence of a suitable salt, at alkaline pH, with an amino derivative of the water-soluble, nonimmunogenic polymer, polyvinyl alcohol (PVA).
Claim 3
Dependent Claim
34 words
A process as stated in claim 1, wherein the amino derivative of PVA is prepared by reacting 1,6-hexanediamine with polyvinyl alcohols which had been activated with cyanogen bromide at a pH range of 9-11.
Claim 4
Dependent Claim
22 words
A process as stated in claim 1, wherein the polyvinyl alcohol has a molecular weight in the range of 10,000 to 14,000.
Claim 5
Dependent Claim
24 words
A process as stated in claim 1, in which the suitable salts are selected from the group consisting of potassium carbonate and sodium carbonate.
Claim 6
Dependent Claim
17 words
A process as stated in claim 1, in which the alkaline pH had a range of 8-11.
Claim 7
Dependent Claim
52 words
A conjugate consisting of BPO groups coupled to polyvinyl alcohol, suitable for suppressing the formation of reaginic antibodies to penicillin in an allergic host, the conjugate containing an average of 0.7 to 3.9 BPO groups per molecule of polyvinyl alcohol, the said conjugate being prepared according to the process of claim 1.
Claim 8
Dependent Claim
12 words
A process according to claim 1 wherein said alkaline pH is 9.8.
References Cited (Backward Citations)
US2155658A
Cited
DE880046C
Cited
GB1135966A
Cited
US3619371A
Cited
US4261978A
Cited
US4296097A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-06 | 1987-08-08 | 1988-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-06 | 1991-08-08 | 1992-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-06 | 1995-08-08 | 1996-02-07 | $7700.00 | Window Closed / Lapsed |