Patent US4428963A successfully refreshed from Google Patents.
US4428963A
Expired / Lapsed
US
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Novel thiophene derivatives
Assignee: Hoffmann La Roche Inc
•
Filing: 1983-03-10
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Granted: 1984-01-31
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Expires: 2003-03-10
Abstract
Abstract Thiophene derivatives having utility as blood lipid lowering agents and as antiobesity agents are disclosed.
Inventors
- 👤 Pasquale N. Confalone
- 👤 Giacomo Pizzolato
- 👤 Milan R. Uskokovic
- 👤 Marianne Rouge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:05
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38; A; A61; A61K; A61K31/00; A61K31/33; A61K31/38; A61K31/381
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
65 words
A process for reducing blood lipid levels in warm blooded animals which comprises administering an amount of a compound of the formula: ##STR9## wherein R is lower alkyl; R 2 is hydrogen, hydroxy, lower alkoxy, or amino; R 3 and R 4 individually are lower alkyl, aryl, aralkyl or hydrogen; or a pharmaceutically acceptable salt thereof, in an amount effective for reducing blood lipid levels.
Claim 2
Dependent Claim
65 words
A process for reducing blood lipid levels in warm blooded animals which comprises administering an amount of a compound of the formula: ##STR9## wherein R is lower alkyl; R 2 is hydrogen, hydroxy, lower alkoxy, or amino; R 3 and R 4 individually are lower alkyl, aryl, aralkyl or hydrogen; or a pharmaceutically acceptable salt thereof, in an amount effective for reducing blood lipid levels.
Claim 3
Dependent Claim
16 words
The process of claim 1 wherein said compound is: ##STR10## or a pharmaceutically acceptable salt thereof.
Claim 4
Independent Claim
68 words
A method for reducing body fat in warm-blooded animals comprising administering a compound of the formula: ##STR11## wherein R is lower alkyl; R 2 is hydrogen, hydroxy, lower alkoxy, or amino; R 3 and R 4 , which may be the same or different, are lower alkyl, aryl, aralkyl, acyl and hydrogen; or a pharmaceutically acceptable salt thereof, in an amount which is effective as an antiobesity agent.
Claim 5
Independent Claim
68 words
A method for reducing body fat in warm-blooded animals comprising administering a compound of the formula: ##STR11## wherein R is lower alkyl; R 2 is hydrogen, hydroxy, lower alkoxy, or amino; R 3 and R 4 , which may be the same or different, are lower alkyl, aryl, aralkyl, acyl and hydrogen; or a pharmaceutically acceptable salt thereof, in an amount which is effective as an antiobesity agent.
Claim 6
Dependent Claim
16 words
The method of claim 3 wherein the compound is ##STR12## or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
14 words
The process of claim 2 wherein the compound is 4-amino-5-ethyl-3-thiophene carboxylic acid methyl ester.
Claim 8
Dependent Claim
17 words
The process of claim 2 wherein the pharmaceutically acceptable salt is 4-amino-5-ethyl-3-thiophene carboxylic acid methyl ester hydrochloride.
Claim 9
Dependent Claim
12 words
The process of claim 1 wherein the compound is 4-amino-5-ethyl-3-thiophene carboxylic acid.
Claim 10
Dependent Claim
14 words
The method of claim 4 wherein the compound is 4-amino-5-ethyl-3-thiophene carboxylic acid methyl ester.
Claim 11
Dependent Claim
17 words
The method of claim 4 wherein the pharmaceutically acceptable salt is 4-amino-5-ethyl-3-thiophene carboxylic acid methyl ester hydrochloride.
Claim 12
Dependent Claim
12 words
The method of claim 3 wherein the compound is 4-amino-5-ethyl-3-thiophene carboxylic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-30 | 1987-08-01 | 1988-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-30 | 1991-08-01 | 1992-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-30 | 1995-08-01 | 1996-01-31 | $7700.00 | Window Closed / Lapsed |